Mohan Anmol, Godugu Swathi, Joshi Saumya S, Shah Kenisha B, Vanka Srija C, Shakil Hania, P Dhanush, Veliginti Swathi, Sure Prajwal S, Goranti Jyothsna
Department of Medicine, Karachi Medical & Dental College, Karachi, Pakistan.
Department of Medicine, Zaporozhye State Medical University, Zaporozhye, Ukraine.
Ann Med Surg (Lond). 2023 Apr 13;85(5):1784-1789. doi: 10.1097/MS9.0000000000000573. eCollection 2023 May.
The concept of a 'gut-brain axis' was recently developed when the complex communications between the brain and the gut became evident. The interaction may affect emotions, motivation, mood, and higher cognitive functions as well as gut homeostasis. Human microbe symbiosis's merits are now acknowledged to transcend human mental health. Research has recently indicated that the gut-brain axis plays a vital role in brain health maintenance. The term 'gut-brain axis' can only partially capture the intricacy of these interactions. Dysbiosis of the gut commensals has been seen in patients with psychiatric diseases, such as depression. Major depressive disorder is caused by complicated interactions between the individual gene and the environment. In a forced swimming test, P. Zheng discovered that germ-free mice with no gut microbiota had a shorter immobility duration than healthy mice. More radical effects were expressed on the use of probiotics rather than prebiotics and postbiotics in reducing the symptoms of depression in patients with major depressive disorder. One of prime importance can be given to exploring more microbiota to investigate the better therapeutic effects of probiotics, prebiotics, and postbiotics.
当大脑与肠道之间复杂的通讯变得明显时，“肠-脑轴”的概念最近被提出。这种相互作用可能会影响情绪、动机、情绪状态和更高层次的认知功能，以及肠道内环境稳定。现在人们认识到人类微生物共生的益处超越了人类心理健康范畴。最近的研究表明，肠-脑轴在维持大脑健康方面起着至关重要的作用。“肠-脑轴”这个术语只能部分地体现这些相互作用的复杂性。在患有精神疾病（如抑郁症）的患者中，已观察到肠道共生菌的失调。重度抑郁症是由个体基因与环境之间复杂的相互作用引起的。在一项强迫游泳试验中，郑平发现没有肠道微生物群的无菌小鼠的不动时间比健康小鼠短。在减轻重度抑郁症患者的抑郁症状方面，使用益生菌而非益生元和合生元表现出更显著的效果。最重要的一点之一是探索更多的微生物群，以研究益生菌、益生元和合生元更好的治疗效果。
