National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia.
Institute of Physics, Saratov State University, Saratov, Russia.
Sci Rep. 2023 May 25;13(1):8444. doi: 10.1038/s41598-023-35376-1.
We performed a mathematical analysis of functional connectivity in electroencephalography (EEG) of patients with obstructive sleep apnea (OSA) (N = 10; age: 52.8 ± 13 years; median age: 49 years; male/female ratio: 7/3), compared with a group of apparently healthy participants (N = 15; age: 51.5 ± 29.5 years; median age: 42 years; male/female ratio: 8/7), based on the calculation of wavelet bicoherence from nighttime polysomnograms. Having observed the previously known phenomenon of interhemispheric synchronization deterioration, we demonstrated a compensatory increase in intrahemispheric connectivity, as well as a slight increase in the connectivity of the central and occipital areas for high-frequency EEG activity. Significant changes in functional connectivity were extremely stable in groups of apparently healthy participants and OSA patients, maintaining the overall pattern when comparing different recording nights and various sleep stages. The maximum variability of the connectivity was observed at fast oscillatory processes during REM sleep. The possibility of observing some changes in functional connectivity of brain activity in OSA patients in a state of passive wakefulness opens up prospects for further research. Developing the methods of hypnogram evaluation that are independent of functional connectivity may be useful for implementing a medical decision support system.
我们对阻塞性睡眠呼吸暂停（OSA）患者（N=10；年龄：52.8±13 岁；中位数年龄：49 岁；男女比例：7/3）的脑电图（EEG）的功能连接进行了数学分析，并与一组看似健康的参与者（N=15；年龄：51.5±29.5 岁；中位数年龄：42 岁；男女比例：8/7）进行了比较，基于夜间多导睡眠图的小波双相干计算。在观察到已知的大脑半球间同步恶化现象后，我们证明了半球内连接的代偿性增加，以及高频 EEG 活动的中央和枕区连接的轻微增加。在健康参与者和 OSA 患者组中，功能连接的显著变化非常稳定，在比较不同记录之夜和各种睡眠阶段时保持整体模式。在 REM 睡眠期间的快速振荡过程中观察到连接的最大可变性。在被动清醒状态下观察到 OSA 患者脑活动功能连接的一些变化的可能性为进一步研究开辟了前景。开发独立于功能连接的催眠图评估方法可能有助于实现医疗决策支持系统。
