Faculty of Polymer Engineering, Sahand University of Technology, P.O. Box 51335-1996, Tabriz 533184-1133, Iran.
Institute of Polymeric Materials, Sahand University of Technology, P.O. Box 51335-1996, Tabriz 533184-1133, Iran.
Biosensors (Basel). 2023 May 15;13(5):547. doi: 10.3390/bios13050547.
Imatinib mesylate, an anticancer drug, is prescribed to treat gastrointestinal stromal tumors and chronic myelogenous leukemia. A hybrid nanocomposite of N,S-doped carbon dots/carbon nanotube-poly(amidoamine) dendrimer (N,S-CDs/CNTD) was successfully synthesized and used as a significant modifier to design a new and highly selective electrochemical sensor for the determination of imatinib mesylate. A rigorous study with electrochemical techniques, such as cyclic voltammetry and differential pulse voltammetry, was performed to elucidate the electrocatalytic properties of the as-prepared nanocomposite and the preparation procedure of the modified glassy carbon electrode (GCE). A higher oxidation peak current was generated for the imatinib mesylate on a N,S-CDs/CNTD/GCE surface compared to the GCE and CNTD/GCE. The N,S-CDs/CNTD/GCE showed a linear relationship between the concentration and oxidation peak current of the imatinib mesylate in 0.01-100 μM, with a detection limit of 3 nM. Finally, the imatinib mesylate's quantification in blood-serum samples was successfully performed. The N,S-CDs/CNTD/GCE's reproducibility and stability were indeed excellent.
甲磺酸伊马替尼是一种抗癌药物，用于治疗胃肠道间质肿瘤和慢性髓性白血病。成功合成了一种 N，S 掺杂碳点/碳纳米管-聚（酰胺-胺）树枝状大分子（N，S-CDs/CNTD）的杂化纳米复合材料，并将其用作重要修饰剂，设计了一种新的、高选择性的电化学传感器，用于测定甲磺酸伊马替尼。通过电化学技术（如循环伏安法和差分脉冲伏安法）进行了严格的研究，以阐明所制备的纳米复合材料的电催化性质和修饰玻碳电极（GCE）的制备过程。与 GCE 和 CNTD/GCE 相比，N，S-CDs/CNTD/GCE 表面的甲磺酸伊马替尼产生了更高的氧化峰电流。N，S-CDs/CNTD/GCE 显示出甲磺酸伊马替尼在 0.01-100 μM 浓度范围内与氧化峰电流之间的线性关系，检测限为 3 nM。最后，成功地在血清样品中定量了甲磺酸伊马替尼。N，S-CDs/CNTD/GCE 的重现性和稳定性确实非常出色。
