Wu Zhen, Liu Jingjing, Liang Minmin, Zheng Haoyue, Zhu Chuansheng, Wang Yan
Day Chemotherapy Unit, Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Hematology Department, Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Front Chem. 2021 Apr 22;9:670074. doi: 10.3389/fchem.2021.670074. eCollection 2021.
The establishment of a monitoring technique for imatinib is necessary in clinical and environmental toxicology. Leaf extracts of were used as reducing agent for the one-step synthesis of reduced graphene oxide-Ag nanocomposites. This nanocomposite was characterized by TEM, FTIR, XRD, and other instruments. Then, the graphene/Ag nanocomposite was used as a modifier to be cemented on the surface of the glassy carbon electrode. This electrode exhibited excellent electrochemical sensing performance. Under the optimal conditions, the proposed electrode could detect imatinib at 10 nM-0.28 mM with a low limit of detection. This electrochemical sensor also has excellent anti-interference performance and reproducibility.
在临床和环境毒理学中，建立伊马替尼监测技术很有必要。[植物名称]的叶提取物被用作一步合成还原氧化石墨烯-银纳米复合材料的还原剂。该纳米复合材料通过透射电子显微镜（TEM）、傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）等仪器进行表征。然后，将石墨烯/银纳米复合材料用作修饰剂，固定在玻碳电极表面。该电极表现出优异的电化学传感性能。在最佳条件下，所提出的电极能够在10 nM至0.28 mM范围内检测伊马替尼，检测限较低。这种电化学传感器还具有优异的抗干扰性能和重现性。
