Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich at the University Leipzig and the University Clinic Leipzig, AöR, Liebigstraße 20, 04103, Leipzig, Germany.
Department of Medicine III, Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.
Nutr J. 2023 May 27;22(1):28. doi: 10.1186/s12937-023-00856-7.
Obesity and its metabolic sequelae still comprise a challenge when it comes to understanding mechanisms, which drive these pandemic diseases. The human microbiome as a potential key player has attracted the attention of broader research for the past decade. Most of it focused on the gut microbiome while the oral microbiome has received less attention. As the second largest niche, the oral microbiome is associated with a multitude of mechanisms, which are potentially involved in the complex etiology of obesity and associated metabolic diseases. These mechanisms include local effects of oral bacteria on taste perception and subsequent food preference as well as systemic effects on adipose tissue function, the gut microbiome and systemic inflammation. This review summarizes a growing body of research, pointing towards a more prominent role of the oral microbiome in obesity and associated metabolic diseases than expected. Ultimately, our knowledge on the oral microbiome may support the development of new patient oriented therapeutic approaches inevitable to relieve the health burden of metabolic diseases and to reach long-term benefits in patients´ lives.
肥胖及其代谢后果仍然是理解这些流行疾病驱动机制的挑战。人类微生物组作为一个潜在的关键因素，在过去十年中引起了更广泛的研究关注。其中大部分研究集中在肠道微生物组上，而口腔微生物组则受到较少关注。作为第二大生态位，口腔微生物组与许多潜在参与肥胖和相关代谢性疾病复杂病因的机制有关。这些机制包括口腔细菌对味觉感知和随后食物偏好的局部影响，以及对脂肪组织功能、肠道微生物组和全身炎症的系统影响。这篇综述总结了越来越多的研究，指出口腔微生物组在肥胖和相关代谢性疾病中的作用比预期的更为突出。最终，我们对口腔微生物组的了解可能支持开发新的以患者为中心的治疗方法，这对于减轻代谢性疾病的健康负担和患者生活的长期获益是必要的。
