Kang JeongWoo, Chae MyeongJu, Chae HyunYoung, Kwon YongKuk, Lee JiYoun, Hossain Md Akil
Animal Disease Diagnosis Division, Animal and Plant Quarantine Agency (APQA), Ministry of Agriculture, Food and Rural Affairs, 177, Hyeoksin 8-ro, Gimcheon-si 39660, Republic of Korea.
Avian Disease Research Division, Animal and Plant Quarantine Agency (APQA), Ministry of Agriculture, Food and Rural Affairs, 177, Hyeoksin 8-ro, Gimcheon-si 39660, Republic of Korea.
Antibiotics (Basel). 2023 May 9;12(5):876. doi: 10.3390/antibiotics12050876.
A safe and effective method for eradicating poultry red mite (PRM; ) is urgently needed, as existing treatments show a low efficacy or hazardous effects on chickens. We evaluated the efficacy of a combined treatment with ivermectin and allicin (IA) against PRMs in chickens and drug residues in non-target samples. The efficiency of PRM eradication by IA was compared with those of natural acaricides in vitro. Ivermectin (0.25 mg/mL) + allicin (1 mg/mL) (IA compound) was sprayed on isolator housing hens with PRMs. The PRM mortality rate, clinical symptoms, and ivermectin residue in hens were analyzed. IA showed the highest PRM-eradication efficacy among all tested compounds in vitro. The insecticidal rates of IA were 98.7%, 98.4%, 99.4%, and 99.9% at 7, 14, 21, and 28 days of treatment, respectively. After inoculating PRMs, hypersensitivity, itching, and a pale-colored comb were observed in control animals, which were absent in treated hens. No clinical symptoms from IA and ivermectin residues were found in hens. IA effectively exterminated PRMs, demonstrating its potential for industrial use to treat PRMs.
由于现有治疗方法对鸡的疗效较低或有有害影响，因此迫切需要一种安全有效的根除家禽红螨（PRM）的方法。我们评估了伊维菌素和大蒜素联合治疗（IA）对鸡体内PRM的疗效以及非靶标样品中的药物残留。将IA根除PRM的效率与天然杀螨剂在体外的效率进行了比较。将伊维菌素（0.25 mg/mL）+大蒜素（1 mg/mL）（IA化合物）喷洒在装有PRM的隔离舍母鸡身上。分析了母鸡的PRM死亡率、临床症状和伊维菌素残留量。IA在所有测试化合物中体外显示出最高的PRM根除效果。在治疗的第7、14、21和28天，IA的杀虫率分别为98.7%、98.4%、99.4%和99.9%。接种PRM后，对照动物出现过敏、瘙痒和鸡冠变色，而治疗后的母鸡未出现这些症状。在母鸡中未发现IA和伊维菌素残留的临床症状。IA有效地消灭了PRM，证明了其在工业上治疗PRM的潜力。
