Maturana Gabriela, Segovia Javiera, Olea-Azar Claudio, Uribe-Oporto Ernesto, Espinosa Alejandra, Zúñiga-López María Carolina
Department of Inorganic and Analytical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380494, Chile.
Department of Medical Technology, University of Chile, Santiago 8380453, Chile.
Antioxidants (Basel). 2023 May 17;12(5):1108. doi: 10.3390/antiox12051108.
Obesity is a significant health concern affecting 13% of the world's population. It is often associated with insulin resistance and metabolic-associated fatty liver disease (MAFLD), which can cause chronic inflammation in the liver and adipose tissue. Obese hepatocytes show increased lipid droplets and lipid peroxidation, which can lead to the progression of liver damage. Polyphenols have been shown to have the ability to reduce lipid peroxidation, thereby promoting hepatocyte health. Chia leaves, a by-product of chia seed production, are a natural source of bioactive antioxidant compounds, such as cinnamic acids and flavonoids, which have antioxidant and anti-inflammatory properties. In this study, chia leaves' ethanolic extracts of two seed phenotypes were tested on diet-induced obese mice to evaluate their therapeutic potential. Results show that the chia leaf extract positively affected insulin resistance and lipid peroxidation in the liver. In addition, the extract improved the HOMA-IR index compared to the obese control group, reducing the number and size of lipid droplets and lipid peroxidation. These results suggest that chia leaf extract may help treat insulin resistance and liver damage associated with MAFLD.
肥胖是一个重大的健康问题，影响着全球13%的人口。它通常与胰岛素抵抗和代谢相关脂肪性肝病（MAFLD）有关，这可能会导致肝脏和脂肪组织的慢性炎症。肥胖的肝细胞显示出脂质小滴增加和脂质过氧化，这可能导致肝损伤的进展。已证明多酚具有减少脂质过氧化的能力，从而促进肝细胞健康。奇亚叶是奇亚籽生产的副产品，是生物活性抗氧化化合物的天然来源，如肉桂酸和黄酮类化合物，它们具有抗氧化和抗炎特性。在这项研究中，对两种种子表型的奇亚叶乙醇提取物在饮食诱导的肥胖小鼠上进行了测试，以评估其治疗潜力。结果表明，奇亚叶提取物对肝脏中的胰岛素抵抗和脂质过氧化有积极影响。此外，与肥胖对照组相比，该提取物改善了HOMA-IR指数，减少了脂质小滴的数量和大小以及脂质过氧化。这些结果表明，奇亚叶提取物可能有助于治疗与MAFLD相关的胰岛素抵抗和肝损伤。
