Fadwa El-Ouady, Amssayef Ayoub, Eddouks Mohamed
Team of Ethnopharmacology and Pharmacognosy, Department of Biology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia, Morocco.
Cardiovasc Hematol Agents Med Chem. 2022;20(1):60-66. doi: 10.2174/1871525719666210112154340.
The study targeted to evaluate the antihyperglycemic activity of Salvia hispanica.
Salvia hispanica L. (Lamiaceae) is a medicinal plant with many beneficial properties on human health.
This objective of the study was to investigate the antihyperglycemic effect of the aqueous extract of Salvia hispanica (S. hispanica) seeds and its capacity to improve lipid profile in normal and STZ-induced diabetic rats.
The seed aqueous extract of S. hispanica (SHSAE) at a dose of 100 mg/kg was administered orally in normal and diabetic rats. The effect of oral SHSAE treatment on blood glucose and lipid levels during 15 days was assessed in normal and streptozotocin-induced diabetic rats. The oral glucose tolerance test (OGTT) was carried out. The antioxidant activity of SHSAE was also examined.
The decrease of glycemia in rats following the administration of the plant extract suggested that the studied extract possesses antidiabetic effect. The extract of S. hispanica produced hypolipidemic effect with a significant lowering effect on plasma total cholesterol levels and increased on HDL-cholesterol levels. SHSAE was also able to enhance glucose tolerance using OGTT. Moreover, SHSAE possesses a potential antioxidant effect in vitro.
In conclusion, this study demonstrates the antihyperglycemic and antilipidemic effects of SHSAE in rats.
本研究旨在评估芡欧鼠尾草的降血糖活性。
芡欧鼠尾草（唇形科）是一种对人体健康有诸多有益特性的药用植物。
本研究的目的是探究芡欧鼠尾草种子水提取物对正常及链脲佐菌素诱导的糖尿病大鼠的降血糖作用及其改善血脂的能力。
以100mg/kg的剂量给正常和糖尿病大鼠口服芡欧鼠尾草种子水提取物（SHSAE）。在正常和链脲佐菌素诱导的糖尿病大鼠中评估口服SHSAE治疗15天期间对血糖和血脂水平的影响。进行口服葡萄糖耐量试验（OGTT）。还检测了SHSAE的抗氧化活性。
给予植物提取物后大鼠血糖降低，表明所研究的提取物具有抗糖尿病作用。芡欧鼠尾草提取物产生了降血脂作用，对血浆总胆固醇水平有显著降低作用，对高密度脂蛋白胆固醇水平有升高作用。SHSAE还能通过OGTT增强葡萄糖耐量。此外，SHSAE在体外具有潜在的抗氧化作用。
总之，本研究证明了SHSAE对大鼠具有降血糖和降血脂作用。
