Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Nanomedicine. 2020 Nov;30:102297. doi: 10.1016/j.nano.2020.102297. Epub 2020 Sep 12.
This study investigated the synthesis of Pd nanoparticles (NPs) using a high-gravity technique mediated by Salvia hispanica leaf extracts. Biological assays confirmed their antibacterial activity against gram positive (S. aureus) and gram negative (E. coli) bacteria with significant antioxidant activity in comparison with the standards as well as low cellular toxicity on PC12 and HEK293 cell lines. To the best of our knowledge, this study can be considered as the first investigation of Pd-NPs synthesized by Salvia hispanica leaf extracts assisted by a high-gravity technique. In addition, the mentioned green synthesis procedure led to the formation of nanoparticles with considerable antibacterial properties independent of the morphology and texture of the green media of these nanoparticles. Considering the increasing rate of antimicrobial resistant bacteria deaths worldwide, this study introduces a novel green synthesis method and non-antibiotic nanoparticle which should be studied for a wide range of medical applications.
本研究使用经过西班牙鼠尾草叶提取物介导的高重力技术合成钯纳米粒子（NPs）。生物测定证实，与标准品相比，它们对革兰氏阳性（金黄色葡萄球菌）和革兰氏阴性（大肠杆菌）细菌具有抗菌活性，同时具有显著的抗氧化活性，而且对 PC12 和 HEK293 细胞系的细胞毒性较低。据我们所知，这是首次使用西班牙鼠尾草叶提取物辅助高重力技术合成 Pd-NPs 的研究。此外，所述绿色合成方法导致形成具有相当抗菌性能的纳米粒子，而与这些纳米粒子的绿色介质的形态和纹理无关。考虑到全球抗微生物药物耐药菌死亡的发生率不断上升，本研究提出了一种新的绿色合成方法和非抗生素纳米粒子，应该对其进行广泛的医疗应用研究。
