Noble Lara Dominique, Dixon Caitlin, Moran Alison, Trottet Charlotte, Majam Mohammed, Ismail Shameema, Msolomba Vanessa Tiyamike, Mathobela Kegomoditswe, Queval Arthur, George Jaya, Scott Lesley Erica, Stevens Wendy Susan
WITS Diagnostic Innovation Hub, University of the Witwatersrand, Johannesburg 2000, South Africa.
Loop Medical SA, 1015 Lausanne, Vaud, Switzerland.
Diagnostics (Basel). 2023 May 16;13(10):1754. doi: 10.3390/diagnostics13101754.
Blood-based diagnostics are critical for many medical decisions, but mostly rely on venepuncture, which can be inconvenient and painful. The Onflow Serum Gel (Loop Medical SA, Vaud, Lausanne, Switzerland) is a novel blood collection device that utilises needle-free technology to collect capillary blood. In this pilot study, 100 healthy participants were enrolled and provided two Onflow collected specimens and one venous blood specimen. Five chemistry analytes (AST, ALT, LDH, potassium, creatinine) and haemolysis were measured per specimen, and laboratory analyte results were compared. Onflow was found to be more acceptable than venepuncture with lower pain ratings, and 96.5% of participants would use the Onflow method again. All phlebotomists (100%) found Onflow intuitive and user-friendly, with ~1 mL of Onflow blood successfully collected from 99% of participants in <12 min (mean: 6 min, 40 s) and 91% collected on the first attempt. ALT and AST analytes showed no difference in performance, while creatinine generated a negative bias (-5.6 µmol/L), and increased variability was noted with potassium (3.6%CV) and LDH (6.7%CV), although none were clinically relevant. These differences may be due to 35% of Onflow collected specimens having "mild" haemolysis. Onflow is a promising alternative blood collection device that should now be evaluated in participants with expected abnormal chemistries and as an option for self-collection.
基于血液的诊断对于许多医疗决策至关重要，但大多依赖静脉穿刺，这可能带来不便且令人痛苦。Onflow血清凝胶采血器（瑞士洛桑沃州Loop Medical SA公司）是一种新型采血设备，采用无针技术采集毛细血管血。在这项初步研究中，招募了100名健康参与者，他们提供了两份Onflow采集的样本和一份静脉血样本。对每个样本测量了五种化学分析物（谷草转氨酶、谷丙转氨酶、乳酸脱氢酶、钾、肌酐）和溶血情况，并比较了实验室分析物结果。结果发现Onflow比静脉穿刺更易接受，疼痛评分更低，96.5%的参与者愿意再次使用Onflow方法。所有采血人员（100%）都认为Onflow直观且用户友好，99%的参与者在不到12分钟（平均：6分40秒）内成功采集到约1 mL的Onflow血液，91%的采集是首次尝试成功。谷丙转氨酶和谷草转氨酶分析物在性能上无差异，而肌酐产生了负偏差（-5.6 µmol/L），钾（变异系数3.6%）和乳酸脱氢酶（变异系数6.7%）的变异性增加，尽管这些差异在临床上均无相关性。这些差异可能是由于35%的Onflow采集样本有“轻度”溶血。Onflow是一种有前景的替代采血设备，现在应该在预期化学指标异常的参与者中进行评估，并作为自我采血的一种选择。
