Pyrgelis Efstratios-Stylianos, Velonakis Georgios, Papageorgiou Sokratis G, Stefanis Leonidas, Kapaki Elisabeth, Constantinides Vasilios C
1st Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, Vass. Sophias Ave. 74, 11528 Athens, Greece.
Neurochemistry and Biological Markers Unit, 1st Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, Vass. Sophias Ave. 74, 11528 Athens, Greece.
Biomedicines. 2023 Apr 24;11(5):1265. doi: 10.3390/biomedicines11051265.
Idiopathic bormal pressure hydrocephalus (iNPH) is a neurological syndrome that clinically presents with Hakim's triad, namely cognitive impairment, gait disturbances, and urinary incontinence. The fact that iNPH is potentially reversible makes its accurate and early diagnosis of paramount importance. Its main imaging characteristic is the dilation of the brain's ventricular system and the imaging parameters are also included in its diagnostic criteria along with clinical data. There is a variety of different modalities used and a great number of imaging markers that have been described while assessing iNPH patients. The present literature review attempts to describe the most important of these imaging markers and to shed some light on their role in diagnosis, differential diagnosis, and possibly prognosis of this potentially reversible neurological syndrome.
特发性正常压力脑积水（iNPH）是一种神经综合征，临床上表现为哈金三联征，即认知障碍、步态障碍和尿失禁。iNPH具有潜在可逆性这一事实使得其准确早期诊断至关重要。其主要影像学特征是脑室系统扩张，影像学参数连同临床数据也包含在其诊断标准中。在评估iNPH患者时，使用了多种不同的检查方式，并且已经描述了大量的影像学标志物。本综述试图描述这些影像学标志物中最重要的，并阐明它们在这种潜在可逆性神经综合征的诊断、鉴别诊断以及可能的预后中的作用。
