Han Ju Hee, Lee Hyun Ji, Yook Hwa Jung, Han Kyungdo, Lee Ji Hyun, Park Young Min
Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Allergy Asthma Immunol Res. 2023 Jan;15(1):55-66. doi: 10.4168/aair.2023.15.1.55.
Migraine is a relatively common neurologic disorder. A possible link between atopic disorders and migraine has been suggested. This study investigated atopic disorders and their risks of migraine in the Korean population.
From the Korean National Health Insurance Service database, patients aged ≥ 20 years who underwent health screening between January and December of 2009 were enrolled. To evaluate the risk of migraine, Cox proportional hazards regression analyses were performed.
In multivariable analysis, the atopic dermatitis group (adjusted hazard ratio [aHR], 1.28; 95% confidence interval [CI], 1.23-1.33), asthma group (aHR, 1.32; 95% CI, 1.30-1.34) and allergic rhinitis group (aHR, 1.45; 95% CI, 1.44-1.46) had significantly increased risks of migraine compared to their respective control groups ( < 0.001). The patients with 1 (aHR, 1.43; 95% CI, 1.42-1.44), 2 (aHR, 1.50; 95% CI, 1.47-1.53), and 3 (aHR, 1.64; 95% CI, 1.43-1.88) atopic disorders had significantly increased risks of migraine compared to the control group ( < 0.001).
Our results demonstrate that patients with atopic disorders may have increased risk of migraine and that the larger the number of concomitant atopic disorders, the higher the risk of migraine.
偏头痛是一种相对常见的神经系统疾病。已有研究表明特应性疾病与偏头痛之间可能存在联系。本研究调查了韩国人群中的特应性疾病及其患偏头痛的风险。
从韩国国民健康保险服务数据库中，纳入2009年1月至12月期间接受健康筛查的年龄≥20岁的患者。为评估偏头痛风险，进行了Cox比例风险回归分析。
在多变量分析中，与各自的对照组相比，特应性皮炎组（调整后风险比[aHR]，1.28；95%置信区间[CI]，1.23 - 1.33）、哮喘组（aHR，1.32；95% CI，1.30 - 1.34）和过敏性鼻炎组（aHR，1.45；95% CI，1.44 - 1.46）患偏头痛的风险显著增加（<0.001）。与对照组相比，患有1种（aHR，1.43；95% CI，1.42 - 1.44）、2种（aHR，1.50；95% CI，1.47 - 1.53）和3种（aHR，1.64；95% CI，1.43 - 1.88）特应性疾病的患者患偏头痛的风险显著增加（<0.001）。
我们的结果表明，患有特应性疾病的患者可能患偏头痛的风险增加，并且伴随的特应性疾病数量越多，患偏头痛的风险越高。
