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黏膜下注射富血小板血浆对正畸牙齿移动速率的影响——一项双盲、单盲随机对照试验。

Effect of a Submucosal Injection of Platelet-Rich Plasma on the Rate of Orthodontic Tooth Movement - A Split-Mouth, Single-Blind Randomized Controlled Trial.

作者信息

Desai Asavari, Nambiar Supriya, Unnikrishnan Bhaskaran, Rai Sharada, Nayak Sangeeta, Natarajan Srikant

机构信息

Associate Professor, Department of Orthodontics, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, India.

Professor and Head, Department of Orthodontics, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, India.

出版信息

Contemp Clin Dent. 2023 Jan-Mar;14(1):39-44. doi: 10.4103/ccd.ccd_419_21. Epub 2022 Nov 11.

DOI:10.4103/ccd.ccd_419_21
PMID:37250004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10209771/
Abstract

OBJECTIVE

To investigate the effect of submucosal injection of platelet-rich plasma (PRP) on the rate of mini-implant-supported retraction, using a split-mouth randomized clinical design.

MATERIALS AND METHODS

Twenty subjects of either gender between 16 and 25 years of age with bimaxillary dentoalveolar protrusion and crowding of <4 mm scheduled to undergo fixed mechanotherapy with the extraction of 1 premolars; were recruited for the study. Those with a periodontally compromised dentition, blood dyscrasias, smoking/alcoholism, or with a history of fixed orthodontic treatment were not considered. The intervention side received a submucosal injection of autologous PRP which was prepared using 10 ml of the patient's blood. The rate of extraction space closure on both sides was recorded and compared monthly for 3 months using a digital caliper.

RESULTS

Mean overall retraction was faster on the intervention side as compared to the control side by 1.5 times and was statistically significant with a value of 0.001. There was no influence of gender on the rate of retraction. There was no reported swelling or discomfort associated with the PRP injection.

CONCLUSIONS

Submucosal injection of PRP significantly accelerates orthodontic tooth movement and can therefore be used as an effective, safe, and minimally invasive method to expedite orthodontic treatment.

摘要

目的

采用双侧对照随机临床设计，研究黏膜下注射富血小板血浆（PRP）对微型种植体支抗内收速率的影响。

材料与方法

招募20名年龄在16至25岁之间、患有双颌牙牙槽前突且牙列拥挤度小于4mm、计划拔除1颗前磨牙并接受固定机械治疗的受试者。排除患有牙周病损牙列、血液系统疾病、吸烟/酗酒或有固定正畸治疗史的受试者。干预侧接受使用10ml患者自身血液制备的自体PRP黏膜下注射。使用数字卡尺每月记录并比较两侧拔牙间隙关闭速率，为期3个月。

结果

干预侧的平均总体内收速度比对照侧快1.5倍，差异有统计学意义（P值为0.001）。性别对内收速率无影响。未报告与PRP注射相关的肿胀或不适。

结论

黏膜下注射PRP可显著加速正畸牙齿移动，因此可作为一种有效、安全且微创的方法来加速正畸治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/256072188563/CCD-14-39-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/6423f904cd13/CCD-14-39-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/5e9f9656142d/CCD-14-39-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/14e7a31a8b2d/CCD-14-39-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/32dc086d5093/CCD-14-39-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/f36495d0279a/CCD-14-39-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/b665b9f6244c/CCD-14-39-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/256072188563/CCD-14-39-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/6423f904cd13/CCD-14-39-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/5e9f9656142d/CCD-14-39-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/14e7a31a8b2d/CCD-14-39-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/32dc086d5093/CCD-14-39-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/f36495d0279a/CCD-14-39-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/b665b9f6244c/CCD-14-39-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/10209771/256072188563/CCD-14-39-g007.jpg

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