Yan Qiu-Hong, Ni Qing-Rong, Gu Wei-Jie, Liu Hong-Wei, Yuan Xiao-Ying, Sun Jing-Zu
Medical Mycology Center, Department of Dermatology, Air Force Medical Center, Fourth Military Medical University, Beijing, China.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Front Microbiol. 2023 May 12;14:1156027. doi: 10.3389/fmicb.2023.1156027. eCollection 2023.
species are widely distributed with a broad spectrum of hosts and substrates. Generally, these species are entomopathogenic or mycoparasitic. Notably, some isolates of and were obtained from human tissues. In this study, two fungi were isolated from the annular itchy patch of infected skin of a 46-year-old man with diabetes mellitus. Based on a combination of morphological characteristics and phylogenetic analysis, a novel species, , was introduced herein. It morphologically differs from the remaining in the size of phialides and conidia. Additionally, it grows slowly on YPD at 37°C. Antimicrobial susceptibility testing presented that this fungus is resistant to most azole antifungals. Therefore, the diagnosis of tinea faciei was made, and after 2 weeks of being treated with oral terbinafine (250 mg, once a day) and topical terbinafine cream for 1 month, the rash was mainly resolved and no recurrence happened after 6 months of follow-up. Herein, was introduced as a new fungal taxon. Meanwhile, a case of superficial infection caused by was reported. So far, it is the third species obtained from human tissue. Meanwhile, terbinafine is recommended as the first-line antifungal treatment against infection.
该物种分布广泛,宿主和基质种类繁多。一般来说,这些物种是昆虫病原性的或真菌寄生性的。值得注意的是,一些[物种名称1]和[物种名称2]的分离株是从人体组织中获得的。在本研究中,从一名46岁糖尿病男性患者感染皮肤的环形瘙痒斑块中分离出两种真菌。基于形态特征和系统发育分析相结合的方法,在此引入了一个新物种,[新物种名称]。它在瓶梗和分生孢子的大小上与其余[相关物种名称]在形态上有所不同。此外,它在37°C的YPD培养基上生长缓慢。药敏试验表明该真菌对大多数唑类抗真菌药耐药。因此,诊断为面部癣,口服特比萘芬(每日一次,250mg)2周并外用特比萘芬乳膏1个月后,皮疹基本消退,随访6个月无复发。在此,[新物种名称]作为一个新的真菌分类群被引入。同时,报告了1例由[相关物种名称]引起的浅表感染病例。到目前为止,它是从人体组织中获得的第三个[相关物种名称]物种。同时,推荐特比萘芬作为治疗[相关物种名称]感染的一线抗真菌药物。