放射治疗联合免疫疗法成功治疗一例间变性甲状腺癌：病例报告
Radiotherapy combined with immunotherapy successfully treated one case of anaplastic thyroid cancer: A case report.
作者信息
Xing Yurou, Wang Yongsheng, Wu Xin
机构信息
Thoracic Oncology Ward, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Head and Neck Oncology Ward, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
出版信息
Front Oncol. 2023 May 15;13:1125226. doi: 10.3389/fonc.2023.1125226. eCollection 2023.
BACKGROUND
Anaplastic thyroid cancer (ATC) is a rare but highly fatal form of thyroid cancer. This highly malignant tumor progresses rapidly and is prone to relapse and metastasis, with a poor prognosis. Novel treatments have improved survival in recent years, but the outcome of treatment is not satisfactory.
CASE PRESENTATION
We report a case of multiple postoperative recurrences of papillary thyroid carcinoma that later transformed into undifferentiated carcinoma. The patient's neck mass was huge and the operation was unsuitable. Then, she achieved remarkable tumor shrinkage by tislelizumab immunotherapy combined with radiotherapy.
CONCLUSION
This case indicates that radiotherapy combined with immunotherapy is a promising treatment for ATC. Such a combined approach warrants further study.
背景
间变性甲状腺癌（ATC）是一种罕见但极具致命性的甲状腺癌。这种高恶性肿瘤进展迅速，易于复发和转移，预后较差。近年来，新型治疗方法提高了生存率，但治疗结果仍不尽人意。
病例报告
我们报告一例甲状腺乳头状癌术后多次复发，随后转变为未分化癌的病例。患者颈部肿块巨大，手术并不适宜。然后，她通过替雷利珠单抗免疫治疗联合放疗实现了肿瘤显著缩小。
结论
该病例表明，放疗联合免疫治疗是一种有前景的ATC治疗方法。这种联合方法值得进一步研究。
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