Vaxine Pty Ltd, Adelaide, SA, Australia.
School of Pharmacy, University of Nottingham, Nottingham, UK.
Methods Mol Biol. 2023;2673:371-399. doi: 10.1007/978-1-0716-3239-0_26.
Structure-based vaccine design (SBVD) is an important technique in computational vaccine design that uses structural information on a targeted protein to design novel vaccine candidates. This increasing ability to rapidly model structural information on proteins and antibodies has provided the scientific community with many new vaccine targets and novel opportunities for future vaccine discovery. This chapter provides a comprehensive overview of the status of in silico SBVD and discusses the current challenges and limitations. Key strategies in the field of SBVD are exemplified by a case study on design of COVID-19 vaccines targeting SARS-CoV-2 spike protein.
基于结构的疫苗设计（SBVD）是计算疫苗设计中的一项重要技术，它利用靶向蛋白的结构信息来设计新型疫苗候选物。这种快速建模蛋白质和抗体结构信息的能力为科学界提供了许多新的疫苗靶点和未来疫苗发现的新机会。本章全面概述了计算机辅助 SBVD 的现状，并讨论了当前的挑战和局限性。通过针对 SARS-CoV-2 刺突蛋白设计 COVID-19 疫苗的案例研究，举例说明了 SBVD 领域的关键策略。
