Núñez-Carro Carmen, Blanco-Blanco Margarita, Villagrán-Andrade Karla Mariuxi, Blanco Francisco J, de Andrés María C
Unidad de Epigenética, Grupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario, de A Coruña (CHUAC), Sergas, 15006 A Coruña, Spain.
Grupo de Investigación en Reumatología y Salud, Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Fisioterapia, Campus de Oza, Universidade da Coruña (UDC), 15008 A Coruña, Spain.
Pharmaceuticals (Basel). 2023 Jan 21;16(2):156. doi: 10.3390/ph16020156.
Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it has been discovered that epigenetics may play an important role in OA. Our objective is to review the current knowledge of the three classical epigenetic mechanisms-DNA methylation, histone post-translational modifications (PTMs), and non-coding RNA (ncRNA) modifications, including microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs)-in relation to the pathogenesis of OA and focusing on articular cartilage. The search for updated literature was carried out in the PubMed database. Evidence shows that dysregulation of numerous essential cartilage molecules is caused by aberrant epigenetic regulatory mechanisms, and it contributes to the development and progression of OA. This offers the opportunity to consider new candidates as therapeutic targets with the potential to attenuate OA or to be used as novel biomarkers of the disease.
骨关节炎（OA）是一种影响滑膜关节完整性的异质性复杂疾病，尽管其在全球范围内患病率很高，但缺乏有效的治疗方法。近年来，人们发现表观遗传学可能在骨关节炎中起重要作用。我们的目的是回顾目前关于三种经典表观遗传机制——DNA甲基化、组蛋白翻译后修饰（PTMs）和非编码RNA（ncRNA）修饰，包括微小RNA（miRNAs）、环状RNA（circRNAs）和长链非编码RNA（lncRNAs）——与骨关节炎发病机制相关的知识，并重点关注关节软骨。在PubMed数据库中进行了最新文献检索。有证据表明，许多关键软骨分子的失调是由异常的表观遗传调控机制引起的，这促进了骨关节炎的发展和进展。这为考虑将新的候选物作为治疗靶点提供了机会，这些靶点有可能减轻骨关节炎或用作该疾病的新型生物标志物。
