天然生物活性产物作为治疗神经退行性疾病的表观遗传调节剂
Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders.
作者信息
Martínez-Iglesias Olaia, Naidoo Vinogran, Carrera Iván, Corzo Lola, Cacabelos Ramón
机构信息
EuroEspes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Bergondo, Corunna, Spain.
出版信息
Pharmaceuticals (Basel). 2023 Jan 31;16(2):216. doi: 10.3390/ph16020216.
Neurodegenerative disorders (NDDs) are major health issues in Western countries. Despite significant efforts, no effective therapeutics for NDDs exist. Several drugs that target epigenetic mechanisms (epidrugs) have been recently developed for the treatment of NDDs, and several of these are currently being tested in clinical trials. Furthermore, various bioproducts have shown important biological effects for the potential prevention and treatment of these disorders. Here, we review the use of natural products as epidrugs to treat NDDs in order to explore the epigenetic effects and benefits of functional foods and natural bioproducts on neurodegeneration.
神经退行性疾病（NDDs）是西方国家的主要健康问题。尽管付出了巨大努力，但目前尚无针对NDDs的有效治疗方法。最近开发了几种针对表观遗传机制的药物（表观遗传药物）用于治疗NDDs，其中几种目前正在临床试验中进行测试。此外，各种生物制品已显示出对这些疾病具有潜在预防和治疗作用的重要生物学效应。在此，我们综述了天然产物作为表观遗传药物用于治疗NDDs的情况，以探讨功能性食品和天然生物制品对神经退行性变的表观遗传效应和益处。
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