Dirección de Investigación, Instituto Nacional de Geriatría (INGER), Mexico City 10200, Mexico.
Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Nutrients. 2024 Aug 24;16(17):2835. doi: 10.3390/nu16172835.
Aging is the result of the accumulation of a wide variety of molecular and cellular damages over time, meaning that "the more damage we accumulate, the higher the possibility to develop age-related diseases". Therefore, to reduce the incidence of such diseases and improve human health, it becomes important to find ways to combat such damage. In this sense, geroprotectors have been suggested as molecules that could slow down or prevent age-related diseases. On the other hand, nutraceuticals are another set of compounds that align with the need to prevent diseases and promote health since they are biologically active molecules (occurring naturally in food) that, apart from having a nutritional role, have preventive properties, such as antioxidant, anti-inflammatory and antitumoral, just to mention a few. Therefore, in the present review using the specialized databases Scopus and PubMed we collected information from articles published from 2010 to 2023 in order to describe the role of nutraceuticals during the aging process and, given their role in targeting the hallmarks of aging, we suggest that they are potential geroprotectors that could be consumed as part of our regular diet or administered additionally as nutritional supplements.
衰老是随着时间的推移而积累的各种分子和细胞损伤的结果，这意味着“我们积累的损伤越多，患上与年龄相关的疾病的可能性就越高”。因此，为了降低这类疾病的发病率并改善人类健康，寻找对抗这种损伤的方法变得尤为重要。在这种意义上，抗衰老剂被认为是可以减缓或预防与年龄相关的疾病的分子。另一方面，营养保健品是另一组化合物，它们符合预防疾病和促进健康的需求，因为它们是具有生物活性的分子（天然存在于食物中），除了具有营养作用外，还具有预防特性，如抗氧化、抗炎和抗肿瘤等，仅举几例。因此，在本综述中，我们使用专业数据库 Scopus 和 PubMed 收集了 2010 年至 2023 年发表的文章中的信息，以描述营养保健品在衰老过程中的作用，鉴于它们在靶向衰老标志方面的作用，我们认为它们是潜在的抗衰老剂，可以作为我们日常饮食的一部分进行消费，也可以作为营养补充剂额外摄入。
