Centofanti Federica, Buono Alessandro, Verboni Michele, Tomino Carlo, Lucarini Simone, Duranti Andrea, Pandolfi Pier Paolo, Novelli Giuseppe
Department of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy.
Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy.
Pharmaceuticals (Basel). 2023 Feb 5;16(2):240. doi: 10.3390/ph16020240.
Indole-3-carbinol (I3C) is a natural product contained in vegetables belonging to the family and has been studied in recent decades for its biological and pharmacological properties. Herein, we will analyze: (1) the biosynthetic processes and synthetic procedures through which I3C and its main derivatives have been obtained; (2) the characteristics that lead to believe that both I3C and its derivatives are responsible for several important activities-in particular, antitumor and antiviral, through insights concerning in vitro assays and in vivo tests; (3) the mechanisms of action of the most important compounds considered; (4) the potential social impact that the enhancement of the discussed molecules can have in the prevention and treatment of the pathologies' examined field-first of all, those related to respiratory tract disorders and cancer.
吲哚 - 3 - 甲醇（I3C）是十字花科蔬菜中含有的一种天然产物，近几十年来，人们对其生物学和药理学特性进行了研究。在此，我们将分析：（1）获得I3C及其主要衍生物的生物合成过程和合成方法；（2）通过体外试验和体内试验的相关见解，认为I3C及其衍生物具有多种重要活性，特别是抗肿瘤和抗病毒活性的特征；（3）所考虑的最重要化合物的作用机制；（4）所讨论的分子的增强在预防和治疗所研究领域的疾病——首先是与呼吸道疾病和癌症相关的疾病方面可能产生的潜在社会影响。
