离子液体作为将药物成分纳入生物聚合物基药物递送系统的工具。
Ionic Liquids as Tools to Incorporate Pharmaceutical Ingredients into Biopolymer-Based Drug Delivery Systems.
作者信息
Berton Paula, Shamshina Julia L
机构信息
Chemical and Petroleum Engineering Department, University of Calgary, Calgary, AB T2N 1N4, Canada.
Fiber and Biopolymer Research Institute, Department of Plant and Soil Science, Texas Tech University, Lubbock, TX 79409, USA.
出版信息
Pharmaceuticals (Basel). 2023 Feb 11;16(2):272. doi: 10.3390/ph16020272.
This mini-review focuses on the various roles that ionic liquids (ILs) play in the development and applications of biopolymer-based drug delivery systems (DDSs). Biopolymers are particularly attractive as drug delivery matrices due to their biocompatibility, low immunogenicity, biodegradability, and strength, whereas ILs can assist the formation of drug delivery systems. In this work, we showcase the different strategies that were explored using ILs in biopolymer-based DDSs, including impregnation of active pharmaceutical ingredients (APIs)-ILs into biopolymeric materials, employment of the ILs to simplify the process of making the biopolymer-based DDSs, and using the ILs either as dopants or as anchoring agents.
本综述聚焦于离子液体（ILs）在基于生物聚合物的药物递送系统（DDSs）的开发与应用中所发挥的各种作用。生物聚合物作为药物递送基质特别具有吸引力，这归因于它们的生物相容性、低免疫原性、生物可降解性和强度，而离子液体可以辅助药物递送系统的形成。在这项工作中，我们展示了在基于生物聚合物的DDSs中使用离子液体所探索的不同策略，包括将活性药物成分（APIs） - 离子液体浸渍到生物聚合物材料中、利用离子液体简化基于生物聚合物的DDSs的制备过程，以及将离子液体用作掺杂剂或锚固剂。
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