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Ionic Liquids as Tools to Incorporate Pharmaceutical Ingredients into Biopolymer-Based Drug Delivery Systems.

作者信息

Berton Paula, Shamshina Julia L

机构信息

Chemical and Petroleum Engineering Department, University of Calgary, Calgary, AB T2N 1N4, Canada.

Fiber and Biopolymer Research Institute, Department of Plant and Soil Science, Texas Tech University, Lubbock, TX 79409, USA.

出版信息

Pharmaceuticals (Basel). 2023 Feb 11;16(2):272. doi: 10.3390/ph16020272.

DOI:10.3390/ph16020272
PMID:37259417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9963465/
Abstract

This mini-review focuses on the various roles that ionic liquids (ILs) play in the development and applications of biopolymer-based drug delivery systems (DDSs). Biopolymers are particularly attractive as drug delivery matrices due to their biocompatibility, low immunogenicity, biodegradability, and strength, whereas ILs can assist the formation of drug delivery systems. In this work, we showcase the different strategies that were explored using ILs in biopolymer-based DDSs, including impregnation of active pharmaceutical ingredients (APIs)-ILs into biopolymeric materials, employment of the ILs to simplify the process of making the biopolymer-based DDSs, and using the ILs either as dopants or as anchoring agents.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/853aa1d3b599/pharmaceuticals-16-00272-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/ffaef42787d8/pharmaceuticals-16-00272-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/1d348cbe74a1/pharmaceuticals-16-00272-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/c7f2fa3c3503/pharmaceuticals-16-00272-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/cd33cae26556/pharmaceuticals-16-00272-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/e19c2b13537c/pharmaceuticals-16-00272-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/853aa1d3b599/pharmaceuticals-16-00272-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/ffaef42787d8/pharmaceuticals-16-00272-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/1d348cbe74a1/pharmaceuticals-16-00272-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/c7f2fa3c3503/pharmaceuticals-16-00272-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/cd33cae26556/pharmaceuticals-16-00272-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/e19c2b13537c/pharmaceuticals-16-00272-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b2a/9963465/853aa1d3b599/pharmaceuticals-16-00272-sch004.jpg

相似文献

[1]
Ionic Liquids as Tools to Incorporate Pharmaceutical Ingredients into Biopolymer-Based Drug Delivery Systems.

Pharmaceuticals (Basel). 2023-2-11

[2]
Applications of choline-based ionic liquids in drug delivery.

Int J Pharm. 2022-1-25

[3]
Ionic liquids as a useful tool for tailoring active pharmaceutical ingredients.

J Control Release. 2021-10-10

[4]
Ionic Liquids-Based Drug Delivery: a Perspective.

Pharm Res. 2022-10

[5]
Biopolymer-Based Composite Materials Prepared Using Ionic Liquids.

Adv Biochem Eng Biotechnol. 2019

[6]
Polyvinylidene fluoride-Hyaluronic acid wound dressing comprised of ionic liquids for controlled drug delivery and dual therapeutic behavior.

Acta Biomater. 2019-10-4

[7]
Active pharmaceutical ingredients (APIs) in ionic liquids: An effective approach for API physiochemical parameter optimization.

Drug Discov Today. 2022-9

[8]
Ionic liquids as active pharmaceutical ingredients.

ChemMedChem. 2011-5-9

[9]
A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years.

Pharmaceutics. 2024-5-16

[10]
Ionic Liquids as Designed, Multi-Functional Plasticizers for Biodegradable Polymeric Materials: A Mini-Review.

Int J Mol Sci. 2024-1-31

引用本文的文献

[1]
CoO@mSiO nanocomposite supported Pd/ionic liquid as an efficient and magnetically recoverable nanocatalyst.

Sci Rep. 2025-8-24

[2]
A review on oral novel delivery systems of insulin through the novel delivery system formulations: A review.

SAGE Open Med. 2024-1-18

本文引用的文献

[1]
Ionic Liquids-Based Drug Delivery: a Perspective.

Pharm Res. 2022-10

[2]
Fluorescence control of chitin and chitosan fabricated surface functionalization using direct oxidative polymerization.

RSC Adv. 2018-2-13

[3]
Ionic Liquids for Enhanced Drug Delivery: Recent Progress and Prevailing Challenges.

Mol Pharm. 2022-4-4

[4]
Recent Advances in Ionic Liquids in Biomedicine.

Adv Sci (Weinh). 2021-9

[5]
Synthesis of Heparin-Immobilized, Magnetically Addressable Cellulose Nanofibers for Biomedical Applications.

ACS Biomater Sci Eng. 2016-11-14

[6]
Recent advances in ionic liquids and nanotechnology for drug delivery.

Nanomedicine (Lond). 2021-1

[7]
Cellulose Composites with Graphene for Tissue Engineering Applications.

Materials (Basel). 2020-11-25

[8]
Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids.

Eur J Pharm Biopharm. 2020-11

[9]
Potential Application of Ionic Liquids in Pharmaceutical Dosage Forms for Small Molecule Drug and Vaccine Delivery System.

J Pharm Pharm Sci. 2020

[10]
Chitin-calcium alginate composite fibers for wound care dressings spun from ionic liquid solution.

J Mater Chem B. 2014-7-7

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