用于伤口护理敷料的几丁质-海藻酸钙复合纤维,由离子液体溶液纺制而成。
Chitin-calcium alginate composite fibers for wound care dressings spun from ionic liquid solution.
作者信息
Shamshina J L, Gurau G, Block L E, Hansen L K, Dingee C, Walters A, Rogers R D
机构信息
Center for Green Manufacturing and Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487, USA.
出版信息
J Mater Chem B. 2014 Jul 7;2(25):3924-3936. doi: 10.1039/c4tb00329b. Epub 2014 May 19.
Chitin-calcium alginate composite fibers were prepared from a solution of high molecular weight chitin extracted from shrimp shells and alginic acid in the ionic liquid 1-ethyl-3-methylimidazolium acetate by dry-jet wet spinning into an aqueous bath saturated with CaCO. The fibers exhibited a significant proportion of the individual properties of both calcium alginate and chitin. Ultimate stress values were close to values obtained for calcium alginate fibers, and the absorption capacities measured were consistent with those reported for current wound care dressings. Wound healing studies (rat model, histological evaluation) indicated that chitin-calcium alginate covered wound sites underwent normal wound healing with re-epithelialization and that coverage of the dermal fibrosis with hyperplastic epidermis was consistently complete after only 7 days of treatment. Using a single patch per wound per animal during the entire study, all rat wounds achieved 95-99% closure by day 10 with complete wound closure by day 14.
几丁质-海藻酸钙复合纤维是由从虾壳中提取的高分子量几丁质与海藻酸在离子液体1-乙基-3-甲基咪唑醋酸盐中的溶液,通过干喷湿纺法纺丝到饱和碳酸钙水溶液中制备而成。这些纤维展现出海藻酸钙和几丁质各自显著比例的特性。极限应力值接近海藻酸钙纤维所获得的值,并且所测得的吸收能力与当前伤口护理敷料所报道的一致。伤口愈合研究(大鼠模型,组织学评估)表明,覆盖有几丁质-海藻酸钙的伤口部位经历了正常的伤口愈合过程,包括重新上皮化,并且仅在治疗7天后,增生性表皮对真皮纤维化的覆盖就始终是完全的。在整个研究过程中,每只动物每个伤口使用一片敷料,所有大鼠伤口在第10天时实现了95%-99%的闭合,到第14天时伤口完全闭合。