Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil.
Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil.
Nutrition. 2023 Aug;112:112064. doi: 10.1016/j.nut.2023.112064. Epub 2023 Apr 28.
The aim of this systematic review was to investigate whether phase angle (PhA) of bioelectrical impedance is associated with inflammatory markers in cardiovascular diseases (CVDs).
A search was performed in the following databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Latin American Caribbean Health Sciences Literature (LILACS), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science and Scopus; and in the gray literature up to January 2022. Studies with individuals with CVDs were included, to evaluate the association between PhA and the inflammatory markers interleukin (IL)-6, IL-10, IL-18, IL-1β, IL-33, tumor necrosis factor (TNF)-α, C-reactive protein (CRP), toll-like receptor (TLR) 2, TLR 4, nuclear factor κB, pathogen-associated molecular pattern molecules, lipopolysaccharides, interferon-γ-inducing factor, and JAK STAT.
We identified 755 articles and, after an eligibility analysis, 5 studies were included. The inflammatory markers investigated in the studies were CRP, TNF-α, and IL-33. In patients with CVDs, PhA was negatively associated with CRP and TNF-α in 80% and 100% of the studies, respectively.
The present results suggested that PhA is inversely associated with inflammatory markers in individuals with CVDs, and its clinical use is encouraged for better therapeutic planning.
本系统评价旨在探讨生物电阻抗相位角（PhA）与心血管疾病（CVD）中的炎症标志物之间是否存在关联。
我们在以下数据库中进行了检索：MEDLINE、EMBASE、Cochrane 对照试验中心注册库（CENTRAL）、拉丁美洲加勒比健康科学文献（LILACS）、护理学和联合健康文献累积索引（CINAHL）、Web of Science 和 Scopus；并检索了截至 2022 年 1 月的灰色文献。纳入了患有 CVD 的个体的研究，以评估 PhA 与炎症标志物白细胞介素（IL）-6、IL-10、IL-18、IL-1β、IL-33、肿瘤坏死因子（TNF）-α、C 反应蛋白（CRP）、Toll 样受体（TLR）2、TLR 4、核因子 κB、病原体相关分子模式分子、脂多糖、干扰素-γ诱导因子和 JAK-STAT 之间的相关性。
我们共确定了 755 篇文章，经过资格分析后，纳入了 5 项研究。研究中调查的炎症标志物为 CRP、TNF-α 和 IL-33。在 CVD 患者中，PhA 与 CRP 和 TNF-α 呈负相关，在 80%和 100%的研究中分别如此。
本研究结果提示，PhA 与 CVD 患者的炎症标志物呈负相关，鼓励临床应用 PhA 以更好地进行治疗规划。
