Laboratory of Molecular and Cellular Neuroimaging, International Center for Primate Brain Research, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Centre for Hyperpolarisation in Magnetic Resonance, Department of Chemistry, University of York, York, UK.
Nat Chem. 2023 Jun;15(6):755-763. doi: 10.1038/s41557-023-01211-3. Epub 2023 Jun 1.
The development of hyperpolarized bioresponsive probes for magnetic resonance imaging (MRI) applications is an emerging and rapidly growing topic in chemistry. A wide range of hyperpolarized molecular biosensors for functional MRI have been developed in recent years. These probes comprise many different types of small-molecule reporters that can be hyperpolarized using dissolution dynamic nuclear polarization and parahydrogen-induced polarization or xenon-chelated macromolecular conjugates hyperpolarized using spin-exchange optical pumping. In this Perspective, we discuss how the amplified magnetic resonance signals of these agents are responsive to biologically relevant stimuli such as target proteins, reactive oxygen species, pH or metal ions. We examine how functional MRI using these systems allows a great number of biological processes to be monitored rapidly. Consequently, hyperpolarized bioresponsive probes may play a critical role in functional molecular imaging for observing physiology and pathology in real time.
用于磁共振成像 (MRI) 应用的超极化生物响应探针的开发是化学领域中一个新兴且快速发展的课题。近年来，已经开发出了广泛的用于功能 MRI 的超极化分子生物传感器。这些探针包含许多不同类型的小分子报告物，它们可以使用溶解动态核极化和氘诱导极化或使用自旋交换光学泵浦极化的氙螯合大分子缀合物进行超极化。在本观点中，我们讨论了这些试剂的放大磁共振信号如何对靶蛋白、活性氧物种、pH 值或金属离子等生物相关刺激做出响应。我们研究了使用这些系统进行功能 MRI 如何能够快速监测大量的生物过程。因此，超极化生物响应探针在实时观察生理和病理的功能分子成像中可能发挥关键作用。
