Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Lasers Surg Med. 2023 Sep;55(7):636-641. doi: 10.1002/lsm.23679. Epub 2023 Jun 2.
The 730 nm picosecond titanium sapphire laser is a novel laser that shows promising results in treating freckles. This study aimed to further investigate the efficacy and safety of the 730 nm picosecond titanium sapphire laser for treating freckles in Asian patients compared with those of the 755 nm picosecond alexandrite laser.
Each face of 86 participants was split into two parts and randomly assigned either one session of 730 or 755 nm picosecond-laser treatment each. Efficacy and safety were determined based on blinded visual evaluations and self-reports at each follow-up visit.
The treatment outcomes of the 730 nm picosecond laser for the treatment of freckles were comparable to those of the 755 nm picosecond laser, with 68.99 ± 7.42% and 69.27 ± 7.75% clearance, respectively (p > 0.05). Participants achieved similar Global Aesthetic Improvement Scale scores (4.04 ± 0.31 vs. 4.02 ± 0.30, respectively [p > 0.05]). Additionally, the 730 nm picosecond laser was perceived to be less painful than the 755 nm picosecond laser (4.69 ± 1.63 vs. 5.65 ± 1.80 nm, p < 0.0001).
The 730 nm picosecond laser is safe and effective for the treatment of freckles in Asian patients. Besides, the 730 nm picosecond laser is less painful than the 755 nm picosecond laser.
730nm 皮秒钛宝石激光是一种新型激光，在治疗雀斑方面显示出良好的效果。本研究旨在进一步探讨与 755nm 皮秒翠绿宝石激光相比，730nm 皮秒钛宝石激光治疗亚洲患者雀斑的疗效和安全性。
86 名参与者的每一面脸均分为两部分，随机接受 730nm 或 755nm 皮秒激光单次治疗。根据每次随访时的盲法视觉评估和自我报告来确定疗效和安全性。
730nm 皮秒激光治疗雀斑的疗效与 755nm 皮秒激光相当，清除率分别为 68.99±7.42%和 69.27±7.75%（p＞0.05）。参与者的全球美学改善量表评分相似（分别为 4.04±0.31 和 4.02±0.30，p＞0.05）。此外，730nm 皮秒激光被认为比 755nm 皮秒激光疼痛程度更低（4.69±1.63 与 5.65±1.80nm，p＜0.0001）。
730nm 皮秒激光治疗亚洲患者雀斑安全有效，且比 755nm 皮秒激光疼痛程度更低。
