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1

Early On-treatment Changes in Circulating Tumor DNA Fraction and Response to Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer.早期治疗中循环肿瘤 DNA 分数的变化与转移性去势抵抗性前列腺癌对恩杂鲁胺或阿比特龙的反应

Clin Cancer Res. 2023 Aug 1;29(15):2835-2844. doi: 10.1158/1078-0432.CCR-22-2998.

2

Lu-PSMA SPECT Quantitation at 6 Weeks (Dose 2) Predicts Short Progression-Free Survival for Patients Undergoing Lu-PSMA-I&T Therapy.（剂量 2）6 周时 Lu-PSMA SPECT 定量预测 Lu-PSMA-I&T 治疗患者的短期无进展生存期。

J Nucl Med. 2023 Mar;64(3):410-415. doi: 10.2967/jnumed.122.264677. Epub 2022 Sep 8.

3

[F]-Labeled PARP-1 PET imaging of PSMA targeted alpha particle radiotherapy response.[F]-标记的 PARP-1 PET 成像用于 PSMA 靶向 α 粒子放射治疗反应的评估。

Sci Rep. 2022 Jul 29;12(1):13034. doi: 10.1038/s41598-022-17460-0.

4

Identification of tumor tissue-derived DNA methylation biomarkers for the detection and therapy response evaluation of metastatic castration resistant prostate cancer in liquid biopsies.鉴定肿瘤组织来源的DNA甲基化生物标志物用于液体活检中转移性去势抵抗性前列腺癌的检测及治疗反应评估

Mol Cancer. 2022 Jan 3;21(1):7. doi: 10.1186/s12943-021-01445-0.

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Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research.细胞外囊泡作为液体活检中前列腺癌生物标志物的来源：十年研究

Br J Cancer. 2022 Feb;126(3):331-350. doi: 10.1038/s41416-021-01610-8. Epub 2021 Nov 22.

6

Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer.镥 177-PSMA-617 治疗转移性去势抵抗性前列腺癌。

N Engl J Med. 2021 Sep 16;385(12):1091-1103. doi: 10.1056/NEJMoa2107322. Epub 2021 Jun 23.

7

Elucidating Prostate Cancer Behaviour During Treatment via Low-pass Whole-genome Sequencing of Circulating Tumour DNA.通过对循环肿瘤 DNA 进行低深度全基因组测序来阐明治疗过程中的前列腺癌行为。

Eur Urol. 2021 Aug;80(2):243-253. doi: 10.1016/j.eururo.2021.05.030. Epub 2021 Jun 5.

8

Value of Early Circulating Tumor Cells Dynamics to Estimate Docetaxel Benefit in Metastatic Castration-Resistant Prostate Cancer (mCRPC) Patients.早期循环肿瘤细胞动态变化对评估多西他赛在转移性去势抵抗性前列腺癌（mCRPC）患者中的获益价值

Cancers (Basel). 2021 May 12;13(10):2334. doi: 10.3390/cancers13102334.

9

In Comparison to PSA, Interim Ga-68-PSMA PET/CT Response Evaluation Based on Modified RECIST 1.1 After 2 Cycle Is Better Predictor of Overall Survival of Prostate Cancer Patients Treated With Lu-PSMA.与前列腺特异性抗原（PSA）相比，基于改良实体瘤疗效评价标准（RECIST）1.1在2个周期后进行的中期镓-68-前列腺特异性膜抗原（PSMA）正电子发射断层扫描（PET）/计算机断层扫描（CT）反应评估，能更好地预测接受镥-PSMA治疗的前列腺癌患者的总生存期。

Front Oncol. 2021 Mar 17;11:578093. doi: 10.3389/fonc.2021.578093. eCollection 2021.

10

Plasma tumor gene conversions after one cycle abiraterone acetate for metastatic castration-resistant prostate cancer: a biomarker analysis of a multicenter international trial.多中心国际试验的生物标志物分析：转移性去势抵抗性前列腺癌患者使用醋酸阿比特龙治疗一个周期后的血浆肿瘤基因转化。

Ann Oncol. 2021 Jun;32(6):726-735. doi: 10.1016/j.annonc.2021.03.196. Epub 2021 Mar 29.

循环肿瘤 DNA 生物标志物在前列腺癌反应评估中的应用。

Circulating Tumor DNA Biomarkers for Response Assessment in Prostate Cancer.

机构信息

Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota.

出版信息

Clin Cancer Res. 2023 Aug 1;29(15):2745-2747. doi: 10.1158/1078-0432.CCR-23-1043.

DOI:10.1158/1078-0432.CCR-23-1043

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10524714/

Abstract

Circulating tumor DNA (ctDNA) is measurable in the majority of metastatic castration-resistant prostate cancer patients. Data indicate that ctDNA present at baseline can serve as a prognostic biomarker and changes in the ctDNA posttreatment can rapidly predict both time to progression and survival. See related article by Tolmeijer et al., p. 2835.

摘要

循环肿瘤 DNA（ctDNA）在大多数转移性去势抵抗性前列腺癌患者中可测量。数据表明，基线时存在的 ctDNA 可用作预后生物标志物，并且治疗后 ctDNA 的变化可快速预测进展时间和生存。参见 Tolmeijer 等人的相关文章，第 2835 页。