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Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection.癌症患者中导致 SARS-CoV-2 感染不良结局的免疫机制。
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4
Impact of active cancer on COVID-19 survival: a matched-analysis on 557 consecutive patients at an Academic Hospital in Lombardy, Italy.活性癌症对 COVID-19 存活的影响：意大利伦巴第地区一家学术医院 557 例连续患者的匹配分析。
Br J Cancer. 2021 Aug;125(3):358-365. doi: 10.1038/s41416-021-01396-9. Epub 2021 May 11.
5
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6
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The PROCESS 2020 Guideline: Updating Consensus Preferred Reporting Of CasESeries in Surgery (PROCESS) Guidelines.《2020年手术病例系列报告共识优先报告指南（PROCESS）更新指南》
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9
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Int J Surg. 2020 Dec;84:226-230. doi: 10.1016/j.ijsu.2020.10.034. Epub 2020 Nov 9.
10
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白细胞介素-6作为新冠肺炎感染的肝转移性乳腺癌患者生存率的预测指标：病例系列研究

IL-6 as a predictor of survival rate in liver metastatic breast cancer patients with Covid-19 infection: A case series.

作者信息

Setiawati Dea Alberta, Soewoto Widyanti, Saadhi Ikhdin Radiamin

机构信息

Resident of Surgery Department, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, Central Java, Indonesia.

Oncology Surgeon, Department of Surgery, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, Central Java, Indonesia.

出版信息

Int J Surg Case Rep. 2023 Jun;107:108347. doi: 10.1016/j.ijscr.2023.108347. Epub 2023 May 25.

DOI:10.1016/j.ijscr.2023.108347
PMID:37269765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10208658/
Abstract

INTRODUCTION AND IMPORTANCE

Breast cancer is the most common type of cancer in women, with 30 % being metastatic breast cancer. Cancer is known to be a comorbid Covid-19 infection. Interleukin-6 (IL-6) is one of the findings of inflammatory activity due to Covid-19 infection. We report IL-6 levels as a prognostic factor for survival rate in patients with liver metastatic breast cancer.

CASE PRESENTATION

We report five cases of liver metastatic breast cancer with various types of primary breast cancer. All patients are infected with Covid-19. IL-6 levels were reported to be elevated in all five patients. All patients were treated according to the national guidelines for the care of Covid-19 patients. All patients are reported to have deceased after being treated for Covid-19 infection.

CLINICAL DISCUSSION

Metastatic breast cancer has a low prognostic rate. Cancer has been recognized as one of the comorbidities and increases the severity and mortality of Covid-19 infection. Elevated levels of IL-6 are caused by an immune response to infection, and can worsen the outcome of breast cancer patients. Changes in IL-6 levels implicate the survival rate of metastatic breast cancer patients and outcomes during the treatment of Covid-19 infection.

CONCLUSION

Elevated levels of IL-6 can be a prognostic factor of the survival rate of metastatic breast cancer patients during the treatment of Covid-19 infection.

摘要

引言与重要性

乳腺癌是女性中最常见的癌症类型，其中30%为转移性乳腺癌。癌症被认为是新冠病毒19感染的合并症。白细胞介素-6（IL-6）是新冠病毒19感染引起的炎症活动的表现之一。我们报告IL-6水平作为肝转移性乳腺癌患者生存率的预后因素。

病例介绍

我们报告了5例患有不同类型原发性乳腺癌的肝转移性乳腺癌病例。所有患者均感染了新冠病毒19。据报告，所有5例患者的IL-6水平均升高。所有患者均按照国家新冠病毒19患者护理指南进行治疗。据报告，所有患者在接受新冠病毒19感染治疗后均已死亡。

临床讨论

转移性乳腺癌的预后率较低。癌症已被确认为合并症之一，并会增加新冠病毒19感染的严重程度和死亡率。IL-6水平升高是由对感染的免疫反应引起的，会使乳腺癌患者的预后恶化。IL-6水平的变化与转移性乳腺癌患者的生存率以及新冠病毒19感染治疗期间的预后有关。

结论

IL-6水平升高可能是新冠病毒19感染治疗期间转移性乳腺癌患者生存率的预后因素。