Muhammad Arshad M, Farooqi Mohammed F, Bashir Mohamed M, Aldhaheri Aysha S, Agha Adnan
Internal Medicine, Tawam Hospital, Al-Ain, ARE.
Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, ARE.
Cureus. 2023 May 3;15(5):e38477. doi: 10.7759/cureus.38477. eCollection 2023 May.
Hypothyroidism is a common endocrine condition with typical symptoms such as cold intolerance, weight gain, fatigue, constipation, and coarse skin, as well as less common symptoms such as depression, difficulty in concentration, and hair thinning. It is usually diagnosed by combining clinical features and applying clinical judgment; however, the wide spectrum of presenting symptoms can sometimes lead to a diagnostic dilemma. Dysphagia secondary to hypothyroidism is a rarely reported symptom in the literature and is believed to be associated with a hormonal effect on esophageal and gastric motility with neuromuscular incoordination; however, the underlying mechanism remains unknown. The most common cause of hypothyroidism is Hashimoto's disease, which can rarely manifest as heartburn, possibly due to esophageal dysmotility. Herein, we describe an unusual presentation of severe hypothyroidism with dysphagia, for which we could not identify any obstructive cause despite extensive investigations This condition was resolved successfully with levothyroxine treatment. Through this report, we aimed to communicate to the audience the important learning message that hypothyroidism may cause symptoms of dysphagia and to inform practitioners regarding this possibility, which should be considered after ruling out any obstructive pathology.
甲状腺功能减退症是一种常见的内分泌疾病,具有诸如不耐寒、体重增加、疲劳、便秘和皮肤粗糙等典型症状,以及诸如抑郁、注意力难以集中和头发稀疏等不太常见的症状。它通常通过结合临床特征并运用临床判断来诊断;然而,出现症状的范围广泛有时会导致诊断困境。甲状腺功能减退症继发的吞咽困难是文献中很少报道的症状,被认为与激素对食管和胃动力的影响以及神经肌肉不协调有关;然而,其潜在机制仍然未知。甲状腺功能减退症最常见的病因是桥本氏病,它很少表现为烧心,可能是由于食管运动障碍。在此,我们描述了一例伴有吞咽困难的严重甲状腺功能减退症的不寻常表现,尽管进行了广泛检查,我们仍未发现任何梗阻性病因。该病症通过左甲状腺素治疗成功得到解决。通过本报告,我们旨在向读者传达一个重要的经验教训,即甲状腺功能减退症可能导致吞咽困难症状,并告知从业者应考虑到这种可能性,在排除任何梗阻性病变后应加以考虑。