Institut für Organische Chemie, Karlsruher Institut für Technologie (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
J Nat Prod. 2023 Jun 23;86(6):1632-1640. doi: 10.1021/acs.jnatprod.3c00078. Epub 2023 Jun 5.
In this overview the literature on benzo[]fluoranthene-derived toxins produced by fungi is discussed with a view on isolation, structure, biological activities, biosynthesis, and total syntheses of the natural products. This class of compounds consists until now of 33 naturally occurring compounds, where 25 are chiral and eight contain no stereogenic centers. The relative configuration of xylarenol was clarified by comparison of experimental and calculated ECD spectra, and absolute configurations of four toxins were corrected. The compounds show various biological activities including antibiotic and cytotoxic properties.
本文综述了真菌产生的苯并[ ]荧蒽衍生毒素的文献，讨论了其分离、结构、生物活性、生物合成和天然产物的全合成。这一类化合物迄今包括 33 种天然产物，其中 25 种具有手性，8 种不含手性中心。通过比较实验和计算的 ECD 光谱，阐明了木莲醇的相对构型，并修正了四种毒素的绝对构型。这些化合物具有多种生物活性，包括抗生素和细胞毒性。
