生物学中存在天然血红素缺乏，这使得一氧化氮能够通过调节细胞血红素分布来控制血红素蛋白的功能。
A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution.
机构信息
Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
出版信息
Bioessays. 2023 Aug;45(8):e2300055. doi: 10.1002/bies.202300055. Epub 2023 Jun 5.
Abstract
A natural heme deficiency that exists in cells outside of the circulation broadly compromises the heme contents and functions of heme proteins in cells and tissues. Recently, we found that the signaling molecule, nitric oxide (NO), can trigger or repress the deployment of intracellular heme in a concentration-dependent hormetic manner. This uncovers a new role for NO and sets the stage for it to shape numerous biological processes by controlling heme deployment and consequent heme protein functions in biology.
摘要
天然血红素缺乏广泛存在于循环系统之外的细胞中，这会严重影响细胞和组织中血红素蛋白的血红素含量和功能。最近，我们发现信号分子一氧化氮（NO）可以以浓度依赖的适应原方式触发或抑制细胞内血红素的释放。这揭示了 NO 的一个新角色，并为其通过控制血红素的释放和随后的血红素蛋白功能来塑造众多生物学过程奠定了基础。
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