Tang Mingwei, Han Yubing, Jia Danchen, Yang Qing, Cheng Ji-Xin
State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
Intelligent Perception Research Institute, Zhejiang Lab, Hangzhou, 311100, China.
Light Sci Appl. 2023 Jun 5;12(1):137. doi: 10.1038/s41377-023-01182-7.
Far-field chemical microscopy providing molecular electronic or vibrational fingerprint information opens a new window for the study of three-dimensional biological, material, and chemical systems. Chemical microscopy provides a nondestructive way of chemical identification without exterior labels. However, the diffraction limit of optics hindered it from discovering more details under the resolution limit. Recent development of super-resolution techniques gives enlightenment to open this door behind far-field chemical microscopy. Here, we review recent advances that have pushed the boundary of far-field chemical microscopy in terms of spatial resolution. We further highlight applications in biomedical research, material characterization, environmental study, cultural heritage conservation, and integrated chip inspection.
提供分子电子或振动指纹信息的远场化学显微镜为三维生物、材料和化学系统的研究打开了一扇新窗口。化学显微镜提供了一种无需外部标记的化学识别无损方法。然而，光学的衍射极限阻碍了它在分辨率极限以下发现更多细节。超分辨率技术的最新发展为打开远场化学显微镜背后的这扇门提供了启示。在这里，我们回顾了在空间分辨率方面推动远场化学显微镜边界的最新进展。我们进一步强调了其在生物医学研究、材料表征、环境研究、文化遗产保护和集成芯片检测中的应用。
