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四种不同分子量的玛咖多糖的结构表征及α-葡萄糖苷酶抑制活性

Structural characterizations and α-glucosidase inhibitory activities of four Lepidium meyenii polysaccharides with different molecular weights.

作者信息

Wen Luan, Wu Zhou-Wei, Lin Li-Wu, Al-Romaima Abdulbaset, Peng Xing-Rong, Qiu Ming-Hua

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China.

University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2023 Jun 6;13(1):18. doi: 10.1007/s13659-023-00384-1.

DOI:10.1007/s13659-023-00384-1
PMID:37278859
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10244309/
Abstract

Four polysaccharides (MCPa, MCPb, MCPc, MCPd) were obtained from Lepidium meyenii Walp. Their structures were characterized by chemical and instrumental methods including total sugar, uronic acid and protein content determination, UV, IR and NMR spectroscopy, as well as monosaccharide composition determination and methylation analyses. Four polysaccharides were a group of glucans with different molecular weights ranging from 3.12 to 14.4 kDa, and shared a similar backbone chain consisting of (1→4)-glucose linkages with branches attached to C-3 and C-6. Furthermore, bioactivity assay showed that MCPs had concentration-dependent inhibitory activity on α-glucosidase. MCPb (Mw = 10.1 kDa) and MCPc (Mw = 5.62 kDa) with moderate molecular weights exhibited higher inhibitory activity compared with MCPa and MCPd.

摘要

从玛咖（Lepidium meyenii Walp.）中获得了四种多糖（MCPa、MCPb、MCPc、MCPd）。通过化学和仪器方法对其结构进行了表征，包括总糖、糖醛酸和蛋白质含量测定、紫外光谱、红外光谱和核磁共振光谱，以及单糖组成测定和甲基化分析。四种多糖是一组葡聚糖，分子量不同，范围为3.12至14.4 kDa，并且具有相似的主链，由（1→4）-葡萄糖连接组成，分支连接在C-3和C-6位。此外，生物活性测定表明，MCPs对α-葡萄糖苷酶具有浓度依赖性抑制活性。与MCPa和MCPd相比，具有中等分子量的MCPb（Mw = 10.1 kDa）和MCPc（Mw = 5.62 kDa）表现出更高的抑制活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b38a/10244309/d5149c77b51b/13659_2023_384_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b38a/10244309/017a19fe382c/13659_2023_384_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b38a/10244309/d5149c77b51b/13659_2023_384_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b38a/10244309/017a19fe382c/13659_2023_384_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b38a/10244309/d5149c77b51b/13659_2023_384_Fig2_HTML.jpg

相似文献

[1]
Structural characterizations and α-glucosidase inhibitory activities of four Lepidium meyenii polysaccharides with different molecular weights.

Nat Prod Bioprospect. 2023-6-6

[2]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
Structural Characterization of a Novel Polysaccharide from Lepidium meyenii (Maca) and Analysis of Its Regulatory Function in Macrophage Polarization in Vitro.

J Agric Food Chem. 2017-2-15

引用本文的文献

[1]
Global Research Status of Maca ( Walp.): A Bibliometric Analysis of Hotspots, Bursts, and Trends.

Drug Des Devel Ther. 2025-3-27

本文引用的文献

[1]
Biopharmaceutical applications of microbial polysaccharides as materials: A Review.

Int J Biol Macromol. 2023-6-1

[2]
Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway.

Front Nutr. 2023-2-16

[3]
Comparative Study on the Structural Properties and Bioactivities of Three Different Molecular Weights of Polysaccharides.

Molecules. 2023-1-10

[4]
Advances in the mechanisms of polysaccharides in alleviating depression and its complications.

Phytomedicine. 2023-1

[5]
Inhibitory effects of fucoidan from Laminaria japonica against some pathogenic bacteria and SARS-CoV-2 depend on its large molecular weight.

Int J Biol Macromol. 2023-2-28

[6]
Diverse meroterpenoids with α-glucosidase inhibitory activity from Ganoderma cochlear.

Fitoterapia. 2023-3

[7]
Maca ( Walp) on semen quality parameters: A systematic review and meta-analysis.

Front Pharmacol. 2022-8-30

[8]
Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (, , and ).

Plants (Basel). 2021-12-26

[9]
Preparation, structure and activity of polysaccharide phosphate esters.

Biomed Pharmacother. 2021-12

[10]
Comparative study of structural properties and biological activities of polysaccharides extracted from Chroogomphus rutilus by four different approaches.

Int J Biol Macromol. 2021-10-1

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