Shrestha Roshana, Gateff Elisabeth
Biologisches Institut I (Zoologie) der Albert-Ludwigs-Universität, Freiburg 7800 Freiburg. i. Br., Schänzlestr. 1, West Germany.
Dev Growth Differ. 1982;24(1):83-98. doi: 10.1111/j.1440-169X.1982.00083.x.
The fine structure and histochemistry of the neoplastic primordial blood cell-types in the larval hematopoietic organs and the mature cell-types in the hemolymph of the blood tumor mutant lethal (1) malignant blood neoplasm (l(1)mbn) of Drosophila melanogaster were investigated. In this mutant the cell-types of the plasmatocyte-line are neoplastic while the cell-types of the crystal-cell-line are not and are much reduced in numbers (1, 2). In contrast to the wild-type the mutant hematopoietic organs are enlarged and contain, in addition to primordial blood-cells, large numbers of mature plasmato-, podo-, and lamellocytes. All cell-types of the plasmatocyte-line differ in their fine structure and behavior from their wild-type counterparts. The mutant blood cells show generally a numerical increase of cell organelles and acid phosphatase positive primary and secondary lysosomes. In the phenol oxidase test they showed a vigorous melanization reaction. Plasmato- and podocytes invade into the tissues of the larva and show high phagocytic activity.
对黑腹果蝇血液肿瘤突变体致死（1）恶性血液肿瘤（l(1)mbn）幼虫造血器官中肿瘤性原始血细胞类型以及血淋巴中成熟细胞类型的精细结构和组织化学进行了研究。在这个突变体中，浆细胞系的细胞类型发生肿瘤性变化，而晶细胞系的细胞类型没有，且数量大幅减少（1,2）。与野生型相比，突变体的造血器官增大，除了原始血细胞外，还含有大量成熟的浆细胞、足细胞和片层细胞。浆细胞系的所有细胞类型在精细结构和行为上都与其野生型对应物不同。突变体血细胞通常显示细胞器数量增加，酸性磷酸酶阳性的初级和次级溶酶体增多。在酚氧化酶试验中，它们表现出强烈的黑化反应。浆细胞和足细胞侵入幼虫组织并表现出高吞噬活性。
