Keshavarzian A, Iber F L, Dangleis M D, Cornish R
Am J Clin Nutr. 1986 Jul;44(1):70-6. doi: 10.1093/ajcn/44.1.70.
Intestinal transit time of lactulose and malabsorption of lactose were measured by hydrogen excretion in breath following ingestion of 20 g lactulose or 25 g lactose. Patients were 20 recently drinking, adequately nourished, chronic, male alcoholics. Many (65%) complained of diarrhea while drinking actively. Small bowel transit was significantly shorter in alcoholics with diarrhea (62 +/- 8.6 min) than in normal controls (93 +/- 10.4 min, p less than 0.05). It increased significantly after 8-10 days abstinence, to a value of 101.5 +/- 11 min, not significantly different from normal controls. Following lactulose 75% of alcoholics developed diarrhea after 1-2 days compared with only 15% after 8-10 days of abstinence; 40% had diarrhea after lactose in the initial study, whereas no subjects had diarrhea from the same dose after a period of sobriety. These data suggest that drinking alcoholics have an increased sensitivity to osmotic loads, which is associated with diarrhea, shortened transit time, and lactose intolerance. Abnormalities disappeared 8-10 days following cessation of drinking and normal diet.
通过摄入20克乳果糖或25克乳糖后呼出气体中的氢排泄量来测量乳果糖的肠道转运时间和乳糖吸收不良情况。患者为20名近期饮酒、营养状况良好的慢性男性酗酒者。许多人（65%）在积极饮酒时抱怨有腹泻症状。有腹泻的酗酒者小肠转运时间（62±8.6分钟）明显短于正常对照组（93±10.4分钟，p<0.05）。戒酒8 - 10天后小肠转运时间显著增加，达到101.5±11分钟，与正常对照组无显著差异。摄入乳果糖后，75%的酗酒者在1 - 2天后出现腹泻，而戒酒8 - 10天后只有15%出现腹泻；在初始研究中，40%的人摄入乳糖后出现腹泻，而在一段清醒期后相同剂量下没有受试者出现腹泻。这些数据表明，饮酒的酗酒者对渗透负荷的敏感性增加，这与腹泻、转运时间缩短和乳糖不耐受有关。停止饮酒并正常饮食8 - 10天后异常情况消失。
