Weissman M M, John K, Merikangas K R, Prusoff B A, Wickramaratne P, Gammon G D, Angold A, Warner V
Am J Dis Child. 1986 Aug;140(8):801-5. doi: 10.1001/archpedi.1986.02140220083038.
Two hundred twenty children (aged 6 to 23 years) from families with either depressed or normal (nonpsychiatrically ill) parents of comparable sociodemographic backgrounds were studied. The children from families in which at least one parent had experienced a major depression were reported to have had more adverse perinatal events; were later in achieving some developmental landmarks; had more convulsions, head injuries, operations, and psychiatric disorders (particularly major depression); and made more suicide attempts. Overall, there were no significant differences in IQ between children in both groups. Mothers in families with a depressed parent reported more medical problems during pregnancy and labor, and the children were reported to have experienced more distress at birth. Since major depression is a highly prevalent disorder in women of childbearing ages, these findings have direct clinical implications for pediatricians. Their specificity for major depression, as contrasted with other psychiatric disorders or chronic illnesses in the parents, requires further study.
对220名儿童（年龄在6至23岁之间）进行了研究，这些儿童来自社会人口背景相当的家庭，其父母一方患有抑郁症，另一方正常（无精神疾病）。据报告，父母中至少有一方曾患重度抑郁症的家庭中的儿童有更多不良围产期事件；在达到一些发育里程碑方面较晚；有更多抽搐、头部受伤、手术和精神疾病（特别是重度抑郁症）；并且有更多自杀企图。总体而言，两组儿童的智商没有显著差异。父母一方患有抑郁症的家庭中的母亲报告在怀孕和分娩期间有更多医疗问题，并且据报告这些儿童在出生时经历了更多痛苦。由于重度抑郁症在育龄女性中是一种高度流行的疾病，这些发现对儿科医生具有直接的临床意义。与父母的其他精神疾病或慢性疾病相比，其对重度抑郁症的特异性需要进一步研究。
