Alves Luísa Valente Gotardo Lara, Fracasso Lisiane Martins, Cortez Thiago Vinicius, Souza-Gabriel Aline Evangelista, Corona Silmara Aparecida Milori
Department of Restorative Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirão Preto, SP, Brazil.
Restor Dent Endod. 2023 Mar 20;48(2):e13. doi: 10.5395/rde.2023.48.e13. eCollection 2023 May.
Natural extracts have been investigated as a biomimetic strategy to mechanically strengthen the collagen network and control the biodegradation of extracellular matrix. This study evaluated the effect of epigallocatechin-3-gallate (EGCG) on abfraction lesions prior to the composite resin.
The sample consisted of 30 patients (aged between 28 and 60 years) with abfraction lesions located in 2 homologous premolars. The teeth were randomly assigned according to dentin treatment: 0.02% EGCG solution or distilled water (control). After enamel acid etching, the solutions were applied immediately for 1 minute. The teeth were restored with Universal Adhesive (3M) and Filtek Z350 XT (3M). Analyzes were done by 2 independent examiners using modified USPHS (retention, secondary caries, marginal adaptation, and postoperative sensitivity) and photographic (color, marginal pigmentation, and anatomical form) criteria at baseline (7 days) and final (18 months). The data analysis used Friedman and Wilcoxon signed-rank tests (α = 0.05).
At baseline, all restorations were evaluated as alpha for all criteria. After 18 months, restorations were evaluated as alpha for secondary caries, color, and marginal pigmentation. There was significant difference between baseline and 18 months ( = 0.009) for marginal adaptation and postoperative sensitivity ( = 0.029), but no significant difference were verified between treatments ( = 0.433). The EGCG group had a restoration retention rate of 93.3%, while the control group had 96.7%.
The application of EGCG solution on abfraction lesions did not significantly influence the survival of the restorations based on clinical and photographic criteria.
天然提取物已被作为一种仿生策略进行研究，以机械增强胶原网络并控制细胞外基质的生物降解。本研究评估了表没食子儿茶素-3-没食子酸酯（EGCG）在复合树脂修复前对楔状缺损病变的影响。
样本包括30例患者（年龄在28至60岁之间），其2颗同源前磨牙存在楔状缺损病变。根据牙本质处理方式将牙齿随机分组：0.02% EGCG溶液或蒸馏水（对照组）。酸蚀牙釉质后，立即应用相应溶液1分钟。使用通用粘结剂（3M）和Filtek Z350 XT（3M）对牙齿进行修复。由2名独立检查者在基线（7天）和最终（18个月）时，根据改良的美国公共卫生服务标准（固位、继发龋、边缘适应性和术后敏感性）以及摄影标准（颜色、边缘色素沉着和解剖形态）进行分析。数据分析采用Friedman检验和Wilcoxon符号秩检验（α = 0.05）。
在基线时，所有修复体在所有标准下均被评估为A级。18个月后，修复体在继发龋、颜色和边缘色素沉着方面被评估为A级。边缘适应性（P = 0.009）和术后敏感性（P = 0.029）在基线和18个月之间存在显著差异，但不同治疗组之间未发现显著差异（P = 0.433）。EGCG组的修复体保留率为93.3%，而对照组为96.7%。
基于临床和摄影标准，EGCG溶液应用于楔状缺损病变对修复体的存留率没有显著影响。
