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超越轻度创伤性脑损伤的症状性诊断。

Beyond symptomatic diagnosis of mild traumatic brain injury.

作者信息

Fawzi Alice Lux, Franck Christian

机构信息

Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.

出版信息

Concussion. 2023 May 22;8(2):CNC109. doi: 10.2217/cnc-2023-0005. eCollection 2023 Jun.

DOI:10.2217/cnc-2023-0005
PMID:37287883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10242431/
Abstract

It is commonly assumed that there is no brain injury if there are no noticeable symptoms following a head impact. There is growing evidence that traumatic brain injuries can occur with no outward symptoms and that the damage from these injuries can accumulate over time resulting in disease and impairment later in life. It is time to rethink the role that symptoms play in traumatic brain injury and adopt a quantitative understanding of brain health at the cellular level to improve the way we diagnose, prevent, and ultimately heal brain injury.

摘要

人们通常认为,如果头部撞击后没有明显症状,就不存在脑损伤。越来越多的证据表明,创伤性脑损伤可能在没有外在症状的情况下发生,而且这些损伤造成的损害会随着时间的推移而累积,导致日后出现疾病和功能障碍。是时候重新思考症状在创伤性脑损伤中所起的作用,并在细胞水平上对脑健康采用定量的理解方式,以改进我们诊断、预防并最终治愈脑损伤的方法了。

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本文引用的文献

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Inflammasome activation in traumatic brain injury and Alzheimer's disease.创伤性脑损伤和阿尔茨海默病中的炎性小体激活。
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Outcomes in Patients With Mild Traumatic Brain Injury Without Acute Intracranial Traumatic Injury.轻度创伤性脑损伤但无脑内急性创伤性损伤患者的结局。
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An acute bout of controlled subconcussive impacts can alter dynamic cerebral autoregulation indices: a preliminary investigation.急性亚阈性冲击可改变动态脑自动调节指数:初步研究。
Eur J Appl Physiol. 2022 Apr;122(4):1059-1070. doi: 10.1007/s00421-022-04908-4. Epub 2022 Feb 16.
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Eye Movements Detect Differential Change after Participation in Male Collegiate Collision versus Non-Collision Sports.参与男子大学碰撞性运动与非碰撞性运动后,眼球运动检测到差异变化。
Neurotrauma Rep. 2021 Oct 7;2(1):440-452. doi: 10.1089/neur.2021.0030. eCollection 2021.
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Head Impact Modeling to Support a Rotational Combat Helmet Drop Test.
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Application of mild hypothermia successfully mitigates neural injury in a 3D in-vitro model of traumatic brain injury.应用轻度低温成功减轻了创伤性脑损伤三维体外模型中的神经损伤。
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Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets.创伤性脑损伤:病理生理学与潜在治疗靶点
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Finite Element Methods in Human Head Impact Simulations: A Review.有限元方法在人体头部撞击模拟中的应用综述
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