头颈部癌症患者身体活动、炎症标志物与生活质量之间的纵向关联。
Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer.
机构信息
NYU Rory Meyers College of Nursing, New York, New York, USA.
Yale School of Nursing, Orange, Connecticut, USA.
出版信息
Head Neck. 2023 Aug;45(8):1952-1966. doi: 10.1002/hed.27420. Epub 2023 Jun 8.
INTRODUCTION
The aim of this study was to explore the associations among physical activity (PA), inflammatory markers, and quality of life (QoL) from preradiotherapy to 1-year postradiotherapy for patients with head and neck cancer (HNC).
METHODS
This was an observational longitudinal study. Mixed-effect models incorporating within-subject correlation were used to examine the relationship among the three key variables.
RESULTS
Aerobically active patients had significantly lower levels of sTNFR2 (but not other inflammatory markers) than aerobically inactive patients. Being aerobically active and lower inflammation were independently associated with better total QoL scores after adjusting covariates. The trend was similar for patients engaged in strength exercises.
CONCLUSIONS
Being aerobically active was associated with lower inflammation as represented by sTNFR2 but not with other inflammatory markers. Higher PA (aerobic and strength) and lower inflammation were linked to better QoL. More research is warranted to validate the association among PA, inflammation, and QoL.
简介
本研究旨在探讨头颈部癌症（HNC）患者从放疗前到放疗后 1 年期间，体力活动（PA）、炎症标志物与生活质量（QoL）之间的关联。
方法
这是一项观察性纵向研究。采用包含个体内相关性的混合效应模型来检验三个关键变量之间的关系。
结果
与非有氧运动患者相比，有氧运动患者的 sTNFR2 水平显著降低（但其他炎症标志物没有）。在调整协变量后，有氧运动和低炎症水平与更好的总 QoL 评分独立相关。对于进行力量训练的患者，趋势相似。
结论
有氧运动与 sTNFR2 等炎症标志物代表的低炎症有关，但与其他炎症标志物无关。较高的 PA（有氧运动和力量训练）和较低的炎症水平与更好的 QoL 相关。需要进一步的研究来验证 PA、炎症和 QoL 之间的关联。
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