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大流行和疫苗接种中断对过去和现在传染病流行病学的影响。

Impact of pandemics and disruptions to vaccination on infectious diseases epidemiology past and present.

机构信息

UK Health and Value, Pfizer Ltd., Tadworth, UK.

Evidence Synthesis, Evidera, London, UK.

出版信息

Hum Vaccin Immunother. 2023 Aug 1;19(2):2219577. doi: 10.1080/21645515.2023.2219577. Epub 2023 Jun 8.

Abstract

Infectious diseases are a leading cause of morbidity and mortality worldwide with vaccines playing a critical role in preventing deaths. To better understand the impact of low vaccination rates and previous epidemics on infectious disease rates, and how these may help to understand the potential impacts of the current coronavirus disease 2019 (COVID-19) pandemic, a targeted literature review was conducted. Globally, studies suggest past suboptimal vaccine coverage has contributed to infectious disease outbreaks in vulnerable populations. Disruptions caused by the COVID-19 pandemic have contributed to a decline in vaccination uptake and a reduced incidence in several infectious diseases; however, these rates have increased following the lifting of COVID-19 restrictions with modeling studies suggesting a risk of increased morbidity and mortality from several vaccine-preventable diseases. This suggests a window of opportunity to review vaccination and infectious disease control measures before we see further disease resurgence in populations and age-groups currently unaffected.

摘要

传染病是全球发病率和死亡率的主要原因,疫苗在预防死亡方面发挥着关键作用。为了更好地了解低疫苗接种率和以往疫情对传染病发病率的影响,以及这些因素如何帮助我们理解当前 2019 年冠状病毒病(COVID-19)大流行的潜在影响,我们进行了一项有针对性的文献综述。全球范围内的研究表明,过去疫苗接种率不理想导致了弱势群体中的传染病爆发。COVID-19 大流行造成的破坏导致疫苗接种率下降,一些传染病的发病率也有所下降;然而,随着 COVID-19 限制的解除,这些比率有所增加,建模研究表明,几种可通过疫苗预防的疾病的发病率和死亡率增加的风险。这表明,在我们看到目前未受影响的人群和年龄组中疾病再次爆发之前,有机会审查疫苗接种和传染病控制措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62af/10332206/00fbdca0e66c/KHVI_A_2219577_F0001_OC.jpg

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