妥布霉素和庆大霉素在犬体液中分布的比较。
Comparison of the distribution of tobramycin and gentamicin in body fluids of dogs.
作者信息
Szwed J J, Luft F C, Black H R, Elliott R A, Kleit S A
出版信息
Antimicrob Agents Chemother. 1974 May;5(5):444-6. doi: 10.1128/AAC.5.5.444.
Abstract
Tobramycin serum, thoracic lymph, renal lymph, and urine concentrations were measured in mongrel dogs after intravenously administered 5, 10, and 20 mg/kg doses. These were compared with intravenous gentamicin delivered at 5 and 20 mg/kg. Both drugs achieved similar concentrations in serum and thoracic lymph. At 20 mg/kg, tobramycin showed consistently higher renal lymph and urine concentrations than gentamicin. At 5 mg of tobramycin per kg, renal lymph and urine concentrations were higher than with gentamicin only within the 1st h after administration. Thereafter the difference was no longer significant. These data suggest that on the basis of distribution in the body fluids of dogs, tobramycin is a reasonable alternative to gentamicin.
摘要
给杂种犬静脉注射5、10和20mg/kg剂量的妥布霉素后，测定其血清、胸导管淋巴液、肾淋巴液和尿液中的药物浓度。将这些结果与静脉注射5和20mg/kg的庆大霉素进行比较。两种药物在血清和胸导管淋巴液中达到相似的浓度。在20mg/kg剂量时，妥布霉素在肾淋巴液和尿液中的浓度始终高于庆大霉素。在每千克5mg妥布霉素剂量时，肾淋巴液和尿液中的浓度仅在给药后第1小时高于庆大霉素。此后，差异不再显著。这些数据表明，基于在犬体液中的分布情况，妥布霉素是庆大霉素的合理替代药物。
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本文引用的文献
1
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2
3
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5
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