Benoni G, Arosio E, Cuzzolin L, Vaona B, Raimondi M G, Lechi A
Antimicrob Agents Chemother. 1986 May;29(5):906-8. doi: 10.1128/AAC.29.5.906.
The pharmacokinetics of ceftriaxone were studied for seven patients with pleural effusion of various etiologies. All patients received 1 g of antibiotic, administered as an intravenous bolus. The pleural fluid had a high total protein content (6.0 g/dl). Ceftriaxone levels in plasma and in pleural fluid were determined by the agar well diffusion technique. Total and free drug concentrations in pleural fluid reached 7 to 8.7 and 3.8 to 2.3 micrograms/ml, respectively, in 4 to 6 h. The disappearance of the drug from the pleural fluid was very slow. In these patients, therapeutic ceftriaxone levels were present for at least 53 h in pleural fluid.
对7例不同病因胸腔积液患者的头孢曲松药代动力学进行了研究。所有患者均接受1g抗生素，静脉推注给药。胸腔积液总蛋白含量较高（6.0g/dl）。采用琼脂孔扩散技术测定血浆和胸腔积液中的头孢曲松水平。胸腔积液中药物的总浓度和游离浓度分别在4至6小时内达到7至8.7μg/ml和3.8至2.3μg/ml。药物从胸腔积液中的消失非常缓慢。在这些患者中，胸腔积液中头孢曲松的治疗水平至少维持53小时。
