Borrebaeck C A, Rougé P
Arch Biochem Biophys. 1986 Jul;248(1):30-4. doi: 10.1016/0003-9861(86)90397-8.
The mitogenic properties of ten phylogenetically related Lathyrus lectins have been studied. Despite a close structural resemblance and similar carbohydrate specificities, the lectins exhibited significant differences in their ability to induce cell proliferation of human lymphocytes. The differences in optimal dose were in the range 10-30 times. L. ochrus (whole lectin) also had an ability to induce cellular growth 3-10 times better than that of the isolated isolectins, L. ochrus I and II, illustrating the complexity behind the structure-function relation of lectin mitogens.
已对十种系统发育相关的山黧豆凝集素的促有丝分裂特性进行了研究。尽管这些凝集素在结构上极为相似且具有相似的碳水化合物特异性，但它们在诱导人淋巴细胞增殖的能力上表现出显著差异。最佳剂量的差异在10至30倍之间。山黧豆（全凝集素）诱导细胞生长的能力也比分离出的同工凝集素山黧豆I和山黧豆II强3至10倍，这说明了凝集素促有丝分裂原结构与功能关系背后的复杂性。
