Yu V Y, Downe L, Astbury J, Bajuk B
Arch Dis Child. 1986 Jun;61(6):554-8. doi: 10.1136/adc.61.6.554.
Perinatal factors associated with death or disability at 2 years were identified in an inborn cohort of 196 live births with a birth weight of 500-999 g. Antepartum haemorrhage, multiple pregnancy, breech presentation, perinatal asphyxia, hypothermia on admission, hyaline membrane disease, persistent pulmonary hypertension, severe respiratory failure, and intraventricular haemorrhage were associated with increased mortality. Factors associated with increased survival included maternal hypertension, caesarean birth, increasing maturity or size at birth, female sex, and fetal growth retardation. Stepwise multiple discriminant function analysis showed that six factors correctly classified the outcome in 83% of infants: intraventricular haemorrhage was the most important factor followed by the presence of acidosis and hypoxia in the early neonatal period, birth weight, pre-eclamptic toxaemia, and caesarean birth. This study also showed that intraventricular haemorrhage, seizures, antepartum haemorrhage and delay in regaining birth weight were associated with increased disability among survivors.
在一个有196例出生体重为500 - 999克活产儿的出生队列中，确定了与2岁时死亡或残疾相关的围产期因素。产前出血、多胎妊娠、臀位、围产期窒息、入院时体温过低、透明膜病、持续性肺动脉高压、严重呼吸衰竭和脑室内出血与死亡率增加有关。与存活率增加相关的因素包括母亲高血压、剖宫产、出生时成熟度或大小增加、女性性别以及胎儿生长受限。逐步多元判别函数分析表明，六个因素在83%的婴儿中正确分类了结局：脑室内出血是最重要的因素，其次是新生儿早期酸中毒和缺氧的存在、出生体重、先兆子痫、剖宫产。这项研究还表明，脑室内出血、惊厥、产前出血和恢复出生体重延迟与幸存者残疾增加有关。
