类风湿性关节炎相关肾病和狼疮性肾炎中的类风湿因子。
Rheumatoid factor in rheumatoid arthritis associated renal disease and in lupus nephritis.
作者信息
Helin H, Korpela M, Mustonen J, Pasternack A
出版信息
Ann Rheum Dis. 1986 Jun;45(6):508-11. doi: 10.1136/ard.45.6.508.
Abstract
To test the hypothesis that rheumatoid factor (RF) protects against (immune complex mediated) renal disease, patients with rheumatoid arthritis (RA; 48 with nephropathy of various types, 35 without renal disease) and systemic lupus erythematosus (SLE; 35 with and 17 without nephritis) were evaluated for the presence and titre of RF. There was no correlation between RF and nephropathy in RA, whereas in SLE RFs were almost exclusively seen in patients without nephropathy. This result supports the above hypothesis for lupus nephropathy but not for RA associated renal disease, and it may be explained by a more pronounced role for immune complexes in SLE and interference of RFs with the complexes.
摘要
为验证类风湿因子（RF）可预防（免疫复合物介导的）肾脏疾病这一假说，对类风湿关节炎（RA；48例患有各种类型肾病，35例无肾脏疾病）和系统性红斑狼疮（SLE；35例有肾炎，17例无肾炎）患者的RF存在情况及滴度进行了评估。在RA中，RF与肾病之间无相关性，而在SLE中，RF几乎仅见于无肾病的患者。这一结果支持了上述关于狼疮性肾病的假说，但不支持与RA相关的肾脏疾病假说，这可能是由于免疫复合物在SLE中作用更为显著以及RF对复合物的干扰所致。
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