Galera-Davidson H, Bibbo M, Bartels P H, Dytch H E, Puls J H, Wied G L
Anal Quant Cytol Histol. 1986 Jun;8(2):158-67.
The treatment of Hürthle-cell tumors of the thyroid is controversial because of their rarity and the inconsistent histopathologic criteria for their diagnosis. In order to obtain more objective criteria for the management of Hürthle-cell tumors, the nuclear DNA content of cells from 20 cases was measured with the MicroTICAS system and the correlation between the DNA distribution patterns and the clinical and histopathologic findings was evaluated. Three main DNA patterns were found: euploid, polyploid and aneuploid. The euploid or polyploid Hürthle-cell tumors came from patients who did not develop distant metastases or recurrence whereas the aneuploid variants came from patients who died of their disease and/or developed distant metastases and recurrence. Various correlation analyses were performed between DNA ploidy and age, sex, size of tumor, growth pattern, pleomorphism, invasion and metastases. Our data suggests that an aneuploid DNA pattern or one with a large percentage of aneuploid nuclei with DNA content exceeding 5N may predict eventual metastases or recurrence from Hürthle-cell tumor.
甲状腺许特耳细胞肿瘤的治疗存在争议，因为这类肿瘤较为罕见，且诊断的组织病理学标准并不一致。为了获得更客观的许特耳细胞肿瘤管理标准，使用MicroTICAS系统测量了20例病例细胞的核DNA含量，并评估了DNA分布模式与临床及组织病理学发现之间的相关性。发现了三种主要的DNA模式：整倍体、多倍体和非整倍体。整倍体或多倍体许特耳细胞肿瘤来自未发生远处转移或复发的患者，而非整倍体变体则来自死于该疾病和/或发生远处转移及复发的患者。对DNA倍性与年龄、性别、肿瘤大小、生长模式、多形性、侵袭和转移进行了各种相关性分析。我们的数据表明，非整倍体DNA模式或具有大量DNA含量超过5N的非整倍体核的模式可能预示许特耳细胞肿瘤最终会发生转移或复发。
