Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Ophthalmology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Transl Vis Sci Technol. 2023 Jun 1;12(6):7. doi: 10.1167/tvst.12.6.7.
The impact of cataracts on the measurement of macular choriocapillaris flow deficits (CC FDs) was assessed by comparing the quantitative results before and after cataract surgery using an image quality algorithm developed for swept-source optical coherence tomography angiography (SS-OCTA) scans and a validated strategy for quantifying the CC FDs.
SS-OCTA image quality scores and CC FDs measurements within the fovea-centered 1-mm, 3-mm, and 5-mm diameter circles were compared before and after cataract surgery. CC FDs changes in a modified Early Treatment Diabetic Retinopathy Study (ETDRS) grid were further investigated.
Twenty-four eyes were studied. Overall image quality in all three circles was observed to improve significantly following the removal of cataracts (all P < 0.05). Although there was good repeatability in the measurements of CC FDs at both visits (intraclass correlation coefficients were over 0.95), significant decreases in CC FD measurements were observed after surgery within the 1-mm circle (P < 0.001) and the 3-mm circle (P = 0.011), but no changes were observed within the 5-mm circle (P = 0.509) or any of the quadrant sectors of the modified ETDRS grid (all P > 0.05).
The presence of cataracts resulted in worse image quality and increased CC FD measurements within the fovea-centered 1-mm and 3-mm circles, with the 1-mm circle being impacted the most.
The impaired detection of CC perfusion deficits within the central macula of cataract eyes needs to be appreciated when imaging the CC in phakic eyes, especially in clinical trials.
通过比较使用针对扫频源光相干断层扫描血管造影（SS-OCTA）扫描开发的图像质量算法和用于量化脉络膜毛细血管血流缺损（CC FD）的经过验证的策略对白内障手术后黄斑脉络膜毛细血管血流缺损定量结果的影响，评估白内障对黄斑脉络膜毛细血管血流缺损（CC FD）测量的影响。
比较白内障手术前后 SS-OCTA 图像质量评分和以黄斑中心 1mm、3mm 和 5mm 直径圆内的 CC FD 测量值。进一步研究改良早期糖尿病视网膜病变研究（ETDRS）网格中 CC FD 的变化。
共 24 只眼进行了研究。去除白内障后，所有三个圆的整体图像质量均明显提高（均 P < 0.05）。尽管两次就诊时 CC FD 的测量均具有良好的可重复性（组内相关系数均> 0.95），但手术后在 1mm 圆内（P < 0.001）和 3mm 圆内（P = 0.011）观察到 CC FD 测量值显著下降，但在 5mm 圆内（P = 0.509）或改良 ETDRS 网格的任何象限区域内均未观察到变化（均 P > 0.05）。
白内障的存在导致黄斑中心 1mm 和 3mm 圆内的图像质量变差和 CC FD 测量值增加，其中 1mm 圆受影响最大。
在对未白内障眼的脉络膜进行成像时，需要认识到白内障眼中中央黄斑区 CC 灌注缺损的检测受损，尤其是在临床试验中。
