Bandettini L, Filipponi F, Romagnoli P
Cancer. 1986 Aug 1;58(3):685-7. doi: 10.1002/1097-0142(19860801)58:3<685::aid-cncr2820580314>3.0.co;2-#.
This study was undertaken to assess possible modifications of the proliferative activity of colonic mucosa, which could be related to a suggested cancer-promoting role of cholecystectomy. The mitotic index (number of mitoses per 1000 gland cells) was evaluated in the colonic mucosa of 14 healthy subjects, 11 patients with cholelithiasis, before and 6 months after surgery, and 10 patients who had undergone cholecystectomy 2 or more years previously. The mitotic index of cholecystectomized patients was significantly higher than controls. It rose significantly within 6 months of cholecystectomy. The mitotic index of patients with cholelithiasis before surgery was similar to controls. These data suggest that cholecystectomy is followed by an enhancement in the proliferative activity of the colonic mucosa, which could play a cancer-promoting role.
本研究旨在评估结肠黏膜增殖活性可能发生的改变，这可能与胆囊切除术被认为的促癌作用有关。对14名健康受试者、11名胆石症患者（手术前及手术后6个月）以及10名2年或更久之前接受过胆囊切除术的患者的结肠黏膜有丝分裂指数（每1000个腺细胞中的有丝分裂数）进行了评估。胆囊切除患者的有丝分裂指数显著高于对照组。在胆囊切除术后6个月内该指数显著上升。手术前胆石症患者的有丝分裂指数与对照组相似。这些数据表明，胆囊切除术后结肠黏膜的增殖活性增强，这可能起到促癌作用。
