Rossleigh M A, Smith J, Straus D J, Engel I A
Cancer. 1986 Sep 1;58(5):1112-6. doi: 10.1002/1097-0142(19860901)58:5<1112::aid-cncr2820580522>3.0.co;2-b.
Osteonecrosis of the femoral and humeral heads is a serious complication of therapy for Hodgkin's disease and non-Hodgkin's lymphoma. Twenty-five patients were reassessed 5 years after being initially reported, in order to study the further progress and natural history of this complication. In addition, six recent patients who have also developed this condition are presented. With 5-year additional follow-up, no patient had developed symptoms of osteonecrosis in any bone other than those initially involved. Five patients developed severe complications thought to arise from their therapy suggesting that this group of patients were more sensitive to radiation injury than other patients treated with this modality. During the relatively short follow-up 5-year period, a surprising finding was the fact that 31% of the patients with Hodgkin's disease and 50% with non-Hodgkin's lymphoma had died. It is recommended that patients treated for lymphoma with steroid containing chemotherapy and radiotherapy be observed carefully for the occurrence of joint pain. Early diagnosis should lead to attempts to prevent total joint destruction.
股骨头和肱骨头骨坏死是霍奇金病和非霍奇金淋巴瘤治疗的严重并发症。对25例患者在最初报告5年后进行重新评估，以研究该并发症的进一步进展和自然病程。此外，还介绍了6例近期也发生这种情况的患者。经过5年的额外随访，除最初受累的骨骼外，没有患者在其他任何骨骼出现骨坏死症状。5例患者出现了被认为是由其治疗引起的严重并发症，这表明这组患者比接受这种治疗方式的其他患者对放射损伤更敏感。在相对较短的5年随访期内，一个惊人的发现是，31%的霍奇金病患者和50%的非霍奇金淋巴瘤患者已经死亡。建议对接受含类固醇化疗和放疗的淋巴瘤患者仔细观察关节疼痛的发生情况。早期诊断应促使尝试预防全关节破坏。
