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新型聚（2-羟乙基甲基丙烯酸酯）-壳聚糖水凝胶的合成及表征，载氧化铈纳米复合材料敷料用于护理慢性伤口的皮肤伤口愈合。

Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.

机构信息

Department of Nursing, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.

Department of Consumable Reagent, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.

出版信息

IET Nanobiotechnol. 2023 Jun;17(4):312-325. doi: 10.1049/nbt2.12118. Epub 2023 Jun 13.

DOI:10.1049/nbt2.12118
PMID:37312282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10288362/
Abstract

This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound. The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermo gravimetric analysis. The influence of PHEM-CS/CeONPs hydrogels nanocomposites on the gelation time, swelling ratio, in vitro degradation, and mechanical properties was investigated. The as-prepared PHEM-CS/CeONPs hydrogels nanocomposites dressing shows high antimicrobial activity against Staphylococcus aureus and Escherichia coli. Similar trends were observed for the treatment of biofilms where PHEM-CS/CeONPs hydrogels nanocomposites displayed better efficiency. Furthermore, the biological properties of PHEM-CS/CeONPs hydrogels nanocomposites had non-toxic in cell viability and excellent cell adhesion behaviour. After 2 weeks, the wounds treated with the PHEM-CS/CeONPs hydrogels nanocomposite wound dressing achieved a significant closure to 98.5 ± 4.95% compared with the PHEM-CS hydrogels with nearly 71 ± 3.55% of wound closure. Hence, this study strongly supports the possibility of using this novel PHEM-CS/CeONPs hydrogels nanocomposites wound dressing for efficient cutaneous wound healing on chronic wound infection and nursing care.

摘要

本研究旨在基于载氧化铈纳米粒子（CeONPs）的聚（2-羟乙基甲基丙烯酸酯）-壳聚糖（PHEM-CS）水凝胶复合材料来制备伤口敷料，以满足慢性伤口护理中的皮肤伤口愈合需求。通过使用紫外可见光谱、扫描电子显微镜、傅里叶变换红外光谱、X 射线衍射和热重分析对合成的 PHEM-CS/CeONPs 水凝胶纳米复合材料进行了表征。研究了 PHEM-CS/CeONPs 水凝胶纳米复合材料对凝胶时间、溶胀比、体外降解和机械性能的影响。所制备的 PHEM-CS/CeONPs 水凝胶纳米复合材料敷料对金黄色葡萄球菌和大肠杆菌具有高抗菌活性。在治疗生物膜时也观察到了类似的趋势，其中 PHEM-CS/CeONPs 水凝胶纳米复合材料显示出更好的效率。此外，PHEM-CS/CeONPs 水凝胶纳米复合材料具有良好的细胞活力和出色的细胞黏附行为，无细胞毒性。在 2 周后，用 PHEM-CS/CeONPs 水凝胶纳米复合材料处理的伤口实现了 98.5±4.95%的显著闭合，而用 PHEM-CS 水凝胶处理的伤口仅闭合了 71±3.55%。因此，这项研究强烈支持使用这种新型 PHEM-CS/CeONPs 水凝胶纳米复合材料敷料来高效治疗慢性伤口感染和护理中的皮肤伤口愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/241cbfa686f4/NBT2-17-312-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/b50e2f4061bc/NBT2-17-312-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/4323013cb111/NBT2-17-312-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/bf94a9eec294/NBT2-17-312-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/ce99b0b82cbc/NBT2-17-312-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/28e12354a3b6/NBT2-17-312-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/5b1b096aaba8/NBT2-17-312-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/dec8bd6428b1/NBT2-17-312-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/d198639076bc/NBT2-17-312-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/241cbfa686f4/NBT2-17-312-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/b50e2f4061bc/NBT2-17-312-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/4323013cb111/NBT2-17-312-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/bf94a9eec294/NBT2-17-312-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/ce99b0b82cbc/NBT2-17-312-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/28e12354a3b6/NBT2-17-312-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/5b1b096aaba8/NBT2-17-312-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/dec8bd6428b1/NBT2-17-312-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/d198639076bc/NBT2-17-312-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfe3/10288362/241cbfa686f4/NBT2-17-312-g001.jpg

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3
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4
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