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用于剖宫产术后协同增强体内愈合和伤口护理的双金属氧化物杂化纳米复合材料的新型制备

Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.

机构信息

Nursing Department, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, China.

Department of Stomatology, The No. 986 Hospital of the Air Force PLA, Xi'an, Shaanxi, China.

出版信息

Int Wound J. 2022 Nov;19(7):1705-1716. doi: 10.1111/iwj.13771. Epub 2022 Mar 4.

DOI:10.1111/iwj.13771
PMID:35243768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9615299/
Abstract

In the current study, bi-metal oxide hybrid nanocomposites prepared by cerium oxide (CeO ) nanoparticles are included into chitosan-ZnO composites for developing the potential materials of dressing the wound. The wound healing effect of prepared hybrid nanocomposites was evaluated regarding the surface morphology, functional groups, thermal degradation and composite size. The antimicrobial activity of chitosan-ZnO/CeO hybrid nano composites was tested against the pathogens of Staphylococcus aureus and Escherichia coli. The hybrid nanocomposites containing CeO -based chitosan and ZnO nanoparticles were taken for optimum dressing included in the vivo studies on the excisional wounds in wistar rats. After 2 weeks, it is seen that the wound treated with CS-ZnO/CeO hybrid nano composites consists of the significant dressing of nearly 100% compared with control which showed nearly 65% of wound closure. Finally, our reported results gave the proof in supporting the availability of CS-ZnO/CeO hybrid nanocomposites contains the dressing of the wounds for the treatment.

摘要

在本研究中，通过将氧化铈（CeO ）纳米粒子纳入壳聚糖-ZnO 复合材料，制备了双金属氧化物杂化纳米复合材料，以开发潜在的伤口敷料材料。从表面形貌、官能团、热降解和复合材料尺寸等方面评估了制备的杂化纳米复合材料的伤口愈合效果。测试了壳聚糖-ZnO/CeO 杂化纳米复合材料对金黄色葡萄球菌和大肠杆菌病原体的抗菌活性。将含有基于 CeO 的壳聚糖和 ZnO 纳米粒子的杂化纳米复合材料用于最优的伤口敷料，对 Wistar 大鼠的切除伤口进行体内研究。2 周后，与对照组相比，用 CS-ZnO/CeO 杂化纳米复合材料处理的伤口的愈合率接近 100%，而对照组的伤口愈合率接近 65%。最后，我们的研究结果证明了 CS-ZnO/CeO 杂化纳米复合材料的可用性，它包含了伤口的治疗敷料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/f4dd1fe2fff7/IWJ-19-1705-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/38c662b41f9e/IWJ-19-1705-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/5ff7760d5bfd/IWJ-19-1705-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/6f8dafbd7a86/IWJ-19-1705-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/fc8391f0c6cb/IWJ-19-1705-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/f6f864f730c1/IWJ-19-1705-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/7c33435b37ca/IWJ-19-1705-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/3ab40aecf926/IWJ-19-1705-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/6f16893b16d2/IWJ-19-1705-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/78376a99d0e4/IWJ-19-1705-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/f4dd1fe2fff7/IWJ-19-1705-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/38c662b41f9e/IWJ-19-1705-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/5ff7760d5bfd/IWJ-19-1705-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/6f8dafbd7a86/IWJ-19-1705-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/fc8391f0c6cb/IWJ-19-1705-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/f6f864f730c1/IWJ-19-1705-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/7c33435b37ca/IWJ-19-1705-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/3ab40aecf926/IWJ-19-1705-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/6f16893b16d2/IWJ-19-1705-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/78376a99d0e4/IWJ-19-1705-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec1f/9615299/f4dd1fe2fff7/IWJ-19-1705-g002.jpg

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